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Database: UniProt
Entry: R7FGP8_9FIRM
LinkDB: R7FGP8_9FIRM
Original site: R7FGP8_9FIRM 
ID   R7FGP8_9FIRM            Unreviewed;       867 AA.
AC   R7FGP8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Chaperone protein ClpB {ECO:0000256|RuleBase:RU362034};
GN   Name=clpB {ECO:0000256|RuleBase:RU362034};
GN   ORFNames=BN611_02065 {ECO:0000313|EMBL:CDE12852.1};
OS   Ruminococcus sp. CAG:330.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1262954 {ECO:0000313|EMBL:CDE12852.1, ECO:0000313|Proteomes:UP000018377};
RN   [1] {ECO:0000313|EMBL:CDE12852.1, ECO:0000313|Proteomes:UP000018377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:330 {ECO:0000313|Proteomes:UP000018377};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC       involved in the recovery of the cell from heat-induced damage, in
CC       cooperation with DnaK, DnaJ and GrpE. {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBUNIT: Homohexamer. The oligomerization is ATP-dependent.
CC       {ECO:0000256|ARBA:ARBA00026057}.
CC   -!- SUBUNIT: Homohexamer; The oligomerization is ATP-dependent.
CC       {ECO:0000256|RuleBase:RU362034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362034}.
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC       {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDE12852.1}.
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DR   EMBL; CBIH010000116; CDE12852.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7FGP8; -.
DR   STRING; 1262954.BN611_02065; -.
DR   Proteomes; UP000018377; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009408; P:response to heat; IEA:UniProtKB-UniRule.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR017730; Chaperonin_ClpB.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR036628; Clp_N_dom_sf.
DR   InterPro; IPR004176; Clp_R_dom.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR018368; ClpA/B_CS1.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR   PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR   PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF02861; Clp_N; 2.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF81923; Double Clp-N motif; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51903; CLP_R; 1.
DR   PROSITE; PS00870; CLPAB_1; 1.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|RuleBase:RU362034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU362034};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004432};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018377};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW   ProRule:PRU01251}; Stress response {ECO:0000256|RuleBase:RU362034}.
FT   DOMAIN          3..150
FT                   /note="Clp R"
FT                   /evidence="ECO:0000259|PROSITE:PS51903"
FT   COILED          87..114
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
FT   COILED          416..537
FT                   /evidence="ECO:0000256|RuleBase:RU362034"
SQ   SEQUENCE   867 AA;  98019 MW;  9C46388F33CEB045 CRC64;
     MNMEKLTQKS REVIQAANSL AIENQNQQIE QVHLLSALLE QNGGLIPQLF EKMGVAVENV
     QIQLKSSIDA LPAVTGSGRK ADEVYIAQDV DRALREAEKE ASRMKDEYIS VEHLMLGLFD
     AMNSTVRKVL QPFSVTKDAF LEALMKVRGN QRVTTENPEE TYDVLSKYGQ DLVERARAGK
     LDPVIGRDNE IRNVIRILSR KTKNNPVLIG EPGVGKTAIA EGLALRIVRG DVPANLKDRK
     IFSLDLGALI AGAKYRGEFE ERLKAVLNEV KKSEGGIILF IDELHTIVGA GKSDGAMDAG
     NLLKPMLARG ELHCIGATTL NEYRQYIEKD AALERRFQPV MVDEPTVEDT ISILRGLKER
     YEVFHGVKIQ DQALIAAATL SDRYITDRFL PDKAIDLVDE ACAMIRTEMD SMPTELDEIR
     RKIMQHEIEE AALKKEDDKL SKAHLQEVQQ ELSEMRDQFN EMKAKWENEK NAISKVQKLR
     EELEQVNAEI ERAERDYDLN RAAELKYGRL PTLQKELAEE ETIAEKQKEE KDSLLRDKVT
     EEEIARIVGR WTGIPVSKLM EGEREKLLHM EDVLHRRVIG QDEAVTKVSE AILRSRAGIQ
     DPNRPLGSFL FLGPTGVGKT ELAKALAEAL FDDENNIVRI DMSEYMEKFS VSRLIGAPPG
     YVGYEEGGQL TEAVRRKPYS VVLLDEVEKA HPDVFNILLQ VLDDGRITDS QGRTVDFKNT
     IIILTSNLGS PAILEGMDEN GNISETARKE VDALLKQQFR PEFLNRLDEI VFYKPLNRSE
     IFRIVDLLLQ KLKKRLEEKQ LDLEVSQAAK EYIVNEGYDV NYGARPLKRL IQQKLETLVA
     REIIANDPAP DTVIRIDYDG TKLFVKK
//
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