ID   R7GCE3_9CLOT            Unreviewed;       973 AA.
AC   R7GCE3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Putative CoA-substrate-specific enzyme activase {ECO:0000313|EMBL:CDE24760.1};
GN   ORFNames=BN598_01460 {ECO:0000313|EMBL:CDE24760.1};
OS   Clostridium sp. CAG:307.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262795 {ECO:0000313|EMBL:CDE24760.1, ECO:0000313|Proteomes:UP000018128};
RN   [1] {ECO:0000313|EMBL:CDE24760.1, ECO:0000313|Proteomes:UP000018128}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:307 {ECO:0000313|Proteomes:UP000018128};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDE24760.1}.
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DR   EMBL; CBIO010000037; CDE24760.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7GCE3; -.
DR   Proteomes; UP000018128; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018128}.
FT   DOMAIN          3..250
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          312..565
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          656..874
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   973 AA;  108018 MW;  FCB2FB36B7528DAB CRC64;
     MKLGLDVGST TIKYVVLDDN ENIILKDYKR HYSHIKENVL EILNNLKKKG IITDNFKFGI
     SGSAGMGLAN GSHITFVQEV YATRIAANKL IPGTDVIIEL GGEDAKILFL SDGMEVRMNG
     SCAGGTGAFI DQMATLLNVD ITEINGYAKE HEKLYNIASR CGVFAKTDIQ PLLNQGASKS
     DIAASIFKAV VNQTIGGLAQ GREITGKVAY LGGPLTFLSE LQESFNESLH LNGFCPENSL
     YFVALGAAFC ATNDYNINEV IGKIENYHSN SKIGFNAPLF ESQADLEKFR KRHAEDNVKT
     LPLDNYTKPL YLGVDSGSTT LKMVLIDEDL NIRYSKYLSN KGNPVDLFKN ILNDIYTEHP
     YIHIVGASST GYGEELIKNA FNLDGGLVET MAHFKAAKHF MPSVDFIIDI GGQDIKCFKI
     EHGVISNIFL NEACSSGCGS FLQTFANALG YQIEDFAKMG LLAPKPVDLG SRCTVFMNSS
     VKQAQKDGAT IDNISAGLSI SVVKNALYKV IRATNVDSLG KHVVVQGGTF HNEAVLRAFE
     RELNLNVVCP NIAGLMGAYG AALYAKDLGL LNSSILTPEQ LKSFKHEVKF VNCGLCNNRC
     SLTVNSFGAN SKKFISGNRC EKPLTNGIAR SSSLNLYEYI KNRLQSYKPK EGKRGKIGIP
     LVLNNYELLP FWHTFFTSLG FEVINSGFSN AKLFTSGQHT IPSDTVCYPA KLVHGHIEKL
     LGDGIQTIFY PCMSYNIDEH KGDNHYNCPI VAYYPENIKN NVKAIKNITF ISDYLGIFDE
     RKFEKSIYEI LKKYFNDITM KEIKEASKKA YYEYKYHLAD IRVRGKEIIE EARKEGKQII
     VLAGRPYHVD PEVNHGIDKL IAGFDVAIVT EESIAYLEEK FPVNVLNQWT YHARLYAAAK
     YVINQPDMNL VQLVSFGCGL DAVTTDECKD ILERHGKIYT QIKIDEITNL GAVKIRLRSL
     FEALKQEKEA NHD
//