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Database: UniProt
Entry: R7GHA3_9CLOT
LinkDB: R7GHA3_9CLOT
Original site: R7GHA3_9CLOT 
ID   R7GHA3_9CLOT            Unreviewed;       790 AA.
AC   R7GHA3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   03-JUL-2019, entry version 28.
DE   RecName: Full=DNA primase {ECO:0000256|SAAS:SAAS00993443};
DE            EC=2.7.7.- {ECO:0000256|SAAS:SAAS00993444};
GN   ORFNames=BN658_00897 {ECO:0000313|EMBL:CDE25337.1};
OS   Clostridium sp. CAG:440.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium; environmental samples.
OX   NCBI_TaxID=1262807 {ECO:0000313|EMBL:CDE25337.1, ECO:0000313|Proteomes:UP000018067};
RN   [1] {ECO:0000313|EMBL:CDE25337.1, ECO:0000313|Proteomes:UP000018067}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:440 {ECO:0000313|Proteomes:UP000018067};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA polymerase that catalyzes the synthesis of short RNA
CC       molecules used as primers for DNA polymerase during DNA
CC       replication. {ECO:0000256|SAAS:SAAS00709340}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00709317};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS00709320};
CC   -!- SIMILARITY: Belongs to the DnaG primase family.
CC       {ECO:0000256|SAAS:SAAS00709351}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDE25337.1}.
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DR   EMBL; CBIP010000032; CDE25337.1; -; Genomic_DNA.
DR   Proteomes; UP000018067; Unassembled WGS sequence.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003896; F:DNA primase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd03364; TOPRIM_DnaG_primases; 1.
DR   Gene3D; 3.90.580.10; -; 1.
DR   Gene3D; 3.90.980.10; -; 1.
DR   InterPro; IPR013264; DNA_primase_core_N.
DR   InterPro; IPR037068; DNA_primase_core_N_sf.
DR   InterPro; IPR006295; DNA_primase_DnaG.
DR   InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR   InterPro; IPR034151; TOPRIM_DnaG_bac.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR002694; Znf_CHC2.
DR   Pfam; PF13662; Toprim_4; 1.
DR   Pfam; PF08275; Toprim_N; 1.
DR   Pfam; PF01807; zf-CHC2; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SMART; SM00400; ZnF_CHCC; 1.
DR   TIGRFAMs; TIGR01391; dnaG; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018067};
KW   DNA replication {ECO:0000256|SAAS:SAAS00993445};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00709369};
KW   DNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00709327};
KW   Magnesium {ECO:0000256|SAAS:SAAS00709345};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00709338};
KW   Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00709339};
KW   Primosome {ECO:0000256|SAAS:SAAS00709304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018067};
KW   Transcription {ECO:0000256|SAAS:SAAS00709341};
KW   Transferase {ECO:0000256|SAAS:SAAS00993442};
KW   Zinc {ECO:0000256|SAAS:SAAS00709300};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00709301}.
FT   DOMAIN      255    336       Toprim. {ECO:0000259|PROSITE:PS50880}.
FT   COILED      660    684       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   790 AA;  91839 MW;  4F108D063F54168D CRC64;
     MSAYDEILSS SNIIDILEYY GLKVNRNKCI CPFHNDNHPS MMVNANKGIA KCFACGSGGN
     SISFIQKYES EINHNPINTV EAMQKAIEIQ HLNIVLSQNN TTPLTEEQKK KRTLSCILKD
     AIAICEKNLK SKNKDSMRTL DYLKGRNLSE QVINNFHIGF NPSYDNITNK LLSKYNMQDL
     IEVGITKETK SEYVDIFSQR IMIPIFDQYG NPIGFGARVL GDSKPKYINT MTTNLFNKSE
     ILFNYHKAKS FARDYEMIIV EGYMDVISAN AMGFVNTVGI MGTALTKEQI ELLKKLKCEV
     TLSLDNDEAG KNAMIRIIPE LLNEGLDVNV LDISKLKGNF KDFGDLQVAN MKKEDIYKTK
     ISAFIFLLEN KYLLDKELNV DNIFSIYKKM KKDNLIKDTK DILRFKEYIV NKTNLKSEEI
     ENIIMPKEME KESRVDRYKS LYFYYYIMEH LKKYATNHQD RILQKYLESN SISQETIEET
     LNNENYLKDG ENTIDISRYV KEYIYNSDDF IKFKNNKIFI LEKLLDNVKS FNQEGKIVDI
     KLSVEQKDIV LKQYAESFES NIKEYIENNP DEFEDLFIAN NTSQFEKLFP KTYVESLKEQ
     AVNRFKDENV MEAVRYGLAY PDNMKSAMSR QFVNNDKYKT LLIFNNNKNI LGLTPENIIK
     KEITEELEKI KEKSKDKIQK TEIETTKDNK DMSVFIKLSG KEKESFKGIY LPIDSGIQVF
     IPKQLYRIDD GKLQILNSQS KAANMSEYAV DENTKTKKFM NRLTLDNFYH KYFNLYEISM
     EKEVIPSASY
//
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