ID R7H6Z5_9FIRM Unreviewed; 472 AA.
AC R7H6Z5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Biotin and thiamin synthesis-associated domain-containing protein {ECO:0000259|SMART:SM00876};
GN ORFNames=BN645_00768 {ECO:0000313|EMBL:CDE34728.1};
OS Ruminococcus sp. CAG:403.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262958 {ECO:0000313|EMBL:CDE34728.1, ECO:0000313|Proteomes:UP000017925};
RN [1] {ECO:0000313|EMBL:CDE34728.1, ECO:0000313|Proteomes:UP000017925}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:403 {ECO:0000313|Proteomes:UP000017925};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE34728.1}.
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DR EMBL; CBIS010000241; CDE34728.1; -; Genomic_DNA.
DR AlphaFoldDB; R7H6Z5; -.
DR STRING; 1262958.BN645_00768; -.
DR Proteomes; UP000017925; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR GO; GO:0042364; P:water-soluble vitamin biosynthetic process; IEA:UniProt.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR010722; BATS_dom.
DR InterPro; IPR024007; FeFe-hyd_mat_HydG.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR034428; ThiH/NoCL/HydG-like.
DR NCBIfam; TIGR03955; rSAM_HydG; 1.
DR PANTHER; PTHR43583; 2-IMINOACETATE SYNTHASE; 1.
DR PANTHER; PTHR43583:SF2; BIOTIN AND THIAMIN SYNTHESIS ASSOCIATED DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF06968; BATS; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01081; cleavage_of_the_Ca-Cb_bond_in; 1.
DR SFLD; SFLDF00319; Fe_hydrogenase_maturase_(HydG; 1.
DR SMART; SM00876; BATS; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000017925};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 275..383
FT /note="Biotin and thiamin synthesis-associated"
FT /evidence="ECO:0000259|SMART:SM00876"
SQ SEQUENCE 472 AA; 53255 MW; F0B7C7535C0BCC63 CRC64;
MYQPKSMHAE EFINHEEILE TLAYAEQNKS NTALISDILQ KATQCKGLSH REASVLLACE
DPAVLLKMKQ LAEQIKLKFY GNRIVIFAPL YLSNYCVNGC VYCPYHAKNH HITRKKLTQE
DIVREVTALQ DMGHKRLAIE AGEDPLHNPI EYILECIDTI YHIQHRNGAI RRVNVNIAAT
TVENYQKLKQ AGIGTYILFQ ETYHKESYEQ LHPTGPKHNY AYHTEAMDRA MAGGIDDVGL
GVLFGLERYK YEFAALLMHA EHLEAVHGVG PHTISVPRIK RADDIDPSAF HNGIDDETFA
KICALIRIAV PYTGMIISTR ESQAVREKVI RLGVSQISGG SRTSVGGYAI PETEAENSQQ
FDVSDTRTLD EVVQWLMKLG YIPSFCTACY REGRTGDRFM ALCKSGQIQN CCHPNALLTL
KEYLTDYASP ETQAIGLRLI QDELQTIPSP TVQKKTIQYL DAIQNGTRDF RF
//
