ID R7HNC7_9BACT Unreviewed; 784 AA.
AC R7HNC7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RCK C-terminal domain-containing protein {ECO:0000259|PROSITE:PS51202};
GN ORFNames=BN585_01813 {ECO:0000313|EMBL:CDE40880.1};
OS Prevotella sp. CAG:279.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262924 {ECO:0000313|EMBL:CDE40880.1, ECO:0000313|Proteomes:UP000018375};
RN [1] {ECO:0000313|EMBL:CDE40880.1, ECO:0000313|Proteomes:UP000018375}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:279 {ECO:0000313|Proteomes:UP000018375};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE40880.1}.
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DR EMBL; CBIX010000066; CDE40880.1; -; Genomic_DNA.
DR AlphaFoldDB; R7HNC7; -.
DR Proteomes; UP000018375; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018375};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 52..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 617..701
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 705..784
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 784 AA; 85865 MW; 5E844C08917FF9FF CRC64;
MSDFLSQKIF NVPAFNQAFS ASGLPLAQTT TAQTSNAQIS EQQQPSNGET SMISDLGLIL
VVAGIATVLF KRLKQPVVLG YILAGFLVGP HFGYFPTVVD EANIDFWAEL GIIFLLFSLG
LEFSFKKLLN VGGSAAVTVL VIVVGMMATG YTAGRMMDFT NISSLFLGAM LSMSSTTIIM
KALSDLNMSH RRFTPQVLAV LIVEDLFAVI LMVVLSSIAV NNSVSGEDLL WSVFKLSFFL
ILWFLVGVYI IPTFLKRQRR FLTNELLLVL CIGLCFLMVI ASTYSGFSSA LGAFVMGSIL
AGTSEAERMS RVVAPVKDLF GAIFFVSVGM MVDPQVLSTY TVPILILSAI VIVGMIVFGT
GGMLITGQPL RIAIESGFSL VQIGEFSFII ATLGTSLGVI NKTLYPIIVS VSVITTFFTP
YFIKFADPVD RWAEKHLPAR LLALIARYSQ SQTRNESEVT LLWKQALRRT IWRLLIYCVV
LVAILQLSAH LLAPLMESFM STGTAKAFTV GITLAAMAPF LLALCYPSTK KWERTKLKSS
VHSNVPFIAM RLVRIVIAFS FLVYFLFTSY SHTLAISIGA ALFVLVLIYF SKSVRKHMNY
IENVFIANLN ERELRRSGRN NNLVSDMHLA FVNVGYNCPF VGEKLASSNI GHLFGVNVAS
IQRGDRTIPI PGGSTRIFPG DTLGVVGTDE QIQHLLETIE QANIGAANTD ENIDIEFTSV
LLSENSPLNG KKVADVDLRG QYSAMLVSIE HADGTFENPK ADSMMHEGDN IWLVGDKRQI
PKLA
//
