ID R7HQC5_9BACT Unreviewed; 551 AA.
AC R7HQC5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=AMP-binding enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=BN585_00445 {ECO:0000313|EMBL:CDE41496.1};
OS Prevotella sp. CAG:279.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262924 {ECO:0000313|EMBL:CDE41496.1, ECO:0000313|Proteomes:UP000018375};
RN [1] {ECO:0000313|EMBL:CDE41496.1, ECO:0000313|Proteomes:UP000018375}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:279 {ECO:0000313|Proteomes:UP000018375};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE41496.1}.
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DR EMBL; CBIX010000113; CDE41496.1; -; Genomic_DNA.
DR AlphaFoldDB; R7HQC5; -.
DR Proteomes; UP000018375; Unassembled WGS sequence.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000018375}.
FT DOMAIN 37..409
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 459..539
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 551 AA; 62571 MW; 18A422C87ED2F1FD CRC64;
MLEKFLSKTK FDSYEDFMQN FKVNVPENFN FGYDVVDEWA RTNPDKPALL WTNEQGEKIQ
FTFADIKRES DKAASFFTSL GIGRGDMVML ILKRRYQFWF SIIALHKIGA TTIPATHLLT
AKDIVYRCQS ADIKAIVAVG DDIVLKHIDD ALPKCPSLKY RISTGPHIPE GWLDFNKGCA
EAAPFVRPAE ANSNDDISLM YFTSGTTGEP KMVAHSFTYP LGHIITGSYW HNLHEDSLHL
TLADTGWGKA VWGKLYGQWI AGANVFVYDF EKFKPVDVLQ MIHDHHITSF CAPPTVFRFL
IREDLSKFDI SSLKYCTIAG EALNPSVYNE WLRLTGIKLM EGFGQTETTL TIATYPWLEP
KPGSMGKKGP VYDIDLLTSD GRWAEDGEQG EIVVRTGDSR PLGLFKEYYR DPKLTHEAWH
DGIYHTGDVA WRDEDGYYWF IGRKDDVIKS SGYRIGPFEV ESALMTHPAV VECAITGVPD
EIRGQVVKAT IVLSKDYKDR ADEALVKDIQ DHVKRTTAPY KYPRVVEFVD ELPKTISGKI
RRVEIRDKSK K
//
