ID R7HV29_9CLOT Unreviewed; 529 AA.
AC R7HV29;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase {ECO:0000313|EMBL:CDE43220.1};
GN ORFNames=BN648_01589 {ECO:0000313|EMBL:CDE43220.1};
OS Clostridium sp. CAG:411.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262802 {ECO:0000313|EMBL:CDE43220.1, ECO:0000313|Proteomes:UP000018022};
RN [1] {ECO:0000313|EMBL:CDE43220.1, ECO:0000313|Proteomes:UP000018022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:411 {ECO:0000313|Proteomes:UP000018022};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE43220.1}.
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DR EMBL; CBIY010000053; CDE43220.1; -; Genomic_DNA.
DR AlphaFoldDB; R7HV29; -.
DR STRING; 1262802.BN648_01589; -.
DR Proteomes; UP000018022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 115..248
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 257..511
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 37..81
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 529 AA; 60139 MW; 4390B457937FD29B CRC64;
MGIFSGSIND WVFLFGIVLI IVLVCVLVTS WKKSLAERAV YEEKKQLEEN YKELEEAYKQ
LQAANEKLDI KYEELKVSEE RNKKLAYVDY LTELPNRAAF TEYLEYTLST LKKGHILPVM
YIDLDNFKEI NDTLGHSYGD ELLIDCAERL KQVIDKNDYL ARFGGDEFII LSENVINMWE
YENKIQNIQK IFSQPFILSL KEFFITCSVG VAVAPKNSDS AQNLLKNVDV ALYHAKGLGK
NTVSFYEPSL DTHIVTKMET QSELHTAIAN GQFELYYQAQ VDLDSDRIVG FEALVRWNHP
EKGIITADKF IPLAEDTGMI SSIGSWVLFQ ACRQLKEWQD MGFKDLTIAV NLSSRQFKDS
DLVETVEAAI KEAGIHPEDL ELEITESIAL DDITYSIDMI QRLKEIGIKI SLDDFGTGYS
SMNYLKYLPV SNIKIDKSFM ETIIEDKSDK AIVSAIITLA RNFNLDVIAE GVESTEQASF
LKKAQCNIVQ GYLYSVPVSK EDADSLLKNT DAEKIHNMFQ QEETETVQG
//
