ID R7IK92_9BURK Unreviewed; 710 AA.
AC R7IK92;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=(P)ppGpp synthetase I {ECO:0000313|EMBL:CDE52179.1};
GN ORFNames=BN620_02142 {ECO:0000313|EMBL:CDE52179.1};
OS Sutterella sp. CAG:351.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sutterellaceae; Sutterella.
OX NCBI_TaxID=1262975 {ECO:0000313|EMBL:CDE52179.1, ECO:0000313|Proteomes:UP000018107};
RN [1] {ECO:0000313|EMBL:CDE52179.1, ECO:0000313|Proteomes:UP000018107}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:351 {ECO:0000313|Proteomes:UP000018107};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE52179.1}.
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DR EMBL; CBJA010000374; CDE52179.1; -; Genomic_DNA.
DR AlphaFoldDB; R7IK92; -.
DR STRING; 1262975.BN620_02142; -.
DR Proteomes; UP000018107; Unassembled WGS sequence.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
FT DOMAIN 382..443
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 639..710
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 710 AA; 79822 MW; 73B1E6A462832751 CRC64;
MAPDNKKTEA PVKVNWQLAR SMVEPLYAGQ CLETGEPRMS HVDGMASILR GIRDDDELIA
AAYLSSVQDY LKNPEEWIEK SFGSKVLELC TDLQRLMKLS EQARSSNKEA NAASQPEKLR
KMLLAMCGDL RVVLLRLASR LQTLRWFVMH PSDDAKIYAA ETLQLYSPLA NRLGIWQMKW
ELEDLSLRFT RPEVYQEIVR HLDASRAERL AFVQQAVTKI RSLLAAHHIR GEVSGRSKHI
YSIWLKMERK HLPFERLFDL RALRVIVDTV EQCYEVLSIL NENFTAIQSE YDDYIAHPKP
NGYRSLHTVV KASNGLPVEI QIRTREMHEF AELGFAAHWR YKEAGNSLGV NSAEEQKVVW
LRQLLAWHSD VEPPRAPGVE DDLIYALTPM GRVVELAANS TPVDFAYMVH TQLGHRCRGA
KVNGAIVPLT HKLKTGDTVE IIAAKSGGPS QDWMNPELGF AAMARTRGKV RTWFNQLHLQ
EQIARGRDEL DTELARLGKS TYNLESLAKT LGFESVDDLC LTIAKDEISN RAIEAVVLPQ
TQKKAADEPV IPVKPAQPRA HHDNGQILVA GVGSLLTQLA KCCHPVPPDE IVGFVSRGRG
VVVHRADCPN VKNLMEQSKE RLIEVSWGDA PEDTLYPMEI LVLARDRIGL LKDVTDVFIR
LKINITNVNT QTVKNVARLK FGVEVAGAAL MRQALKEILE VKGVISAHRS
//
