ID   R7ISI7_9FIRM            Unreviewed;       725 AA.
AC   R7ISI7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=NAD dependent epimerase/dehydratase family protein {ECO:0000313|EMBL:CDE54243.1};
GN   ORFNames=BN596_02091 {ECO:0000313|EMBL:CDE54243.1};
OS   Roseburia sp. CAG:303.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262944 {ECO:0000313|EMBL:CDE54243.1, ECO:0000313|Proteomes:UP000018355};
RN   [1] {ECO:0000313|EMBL:CDE54243.1, ECO:0000313|Proteomes:UP000018355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:303 {ECO:0000313|Proteomes:UP000018355};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDE54243.1}.
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DR   EMBL; CBJD010000172; CDE54243.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7ISI7; -.
DR   STRING; 1262944.BN596_02091; -.
DR   UniPathway; UPA00124; -.
DR   Proteomes; UP000018355; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008831; F:dTDP-4-dehydrorhamnose reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019305; P:dTDP-rhamnose biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029903; RmlD-like-bd.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF04321; RmlD_sub_bind; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018355};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..254
FT                   /note="RmlD-like substrate binding"
FT                   /evidence="ECO:0000259|Pfam:PF04321"
SQ   SEQUENCE   725 AA;  84520 MW;  880248C941434849 CRC64;
     MNILLIGGEG SLINSMIVKL KKEGHRIYLL TGVQNKKVTY EKVFEKYNFT YDSENLNDIF
     ESVNPDVTIF MGAYDTNFQW KQQEREAVRY SSSLMNILVA YSMTKRGKFI YLSSEEVYSG
     SYPAEIREDE PVSAVGFRGM TLAQGEKICE NYQENWKLDI IILRLDHLYH IPRTSADVDN
     ICARMCISAM EKGYIIADNQ NICSLLYESD AVEFIYRVVK CKTHQHVLYH LTSDRRFREV
     TLARLVAEYM GGNVSVVENE EQGGRRILSG RRFEEEFGIT AFRETEVVLK KMVQYMKKNE
     AVFLDKEEPR LSLWKRVLQK WGWFFRAIVP FLENLLCFVP FFMLNNRVVG SQYFSQLDFY
     LLYVLLFAIV YGQQQATFSA LLATAGYLFR QTYTRSGFEV MLDYNTYVWI AQLFILGLVV
     GYMHDQIRRI RKESEELEAH LSRQLSDIRD INGSNVRVKD VLERQVIDQK DSIGKIYNIT
     SRLDQYMPDE VLFYAVEMLT ELLGSRDVAI YSIANKDYAR MFSAGSVKAR EMGNSIRYRE
     MGEVYQEISA QRVYINRRMD EHYPLMANAI FEEDQMKMII MIWGISWERM TLGQANLLKV
     ISYLIQNAVL RANRYMMALE EKRYLEDTRI LEPEAFTSLA GAYQKARKRN LTECSFLKIE
     TDPSHYLEAG KVLKGNLRQS DYMGNLKDGG LYVLLANTNR EEAGIVVERF EEKGYKSQIV
     ERVEL
//