ID R7JB53_9BACT Unreviewed; 410 AA.
AC R7JB53;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=ATP-dependent zinc metalloprotease FtsH {ECO:0000313|EMBL:CDE60823.1};
GN ORFNames=BN646_01374 {ECO:0000313|EMBL:CDE60823.1};
OS Parabacteroides sp. CAG:409.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Parabacteroides; environmental samples.
OX NCBI_TaxID=1262913 {ECO:0000313|EMBL:CDE60823.1, ECO:0000313|Proteomes:UP000018199};
RN [1] {ECO:0000313|EMBL:CDE60823.1, ECO:0000313|Proteomes:UP000018199}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:409 {ECO:0000313|Proteomes:UP000018199};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|RuleBase:RU003651}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE60823.1}.
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DR EMBL; CBJG010000162; CDE60823.1; -; Genomic_DNA.
DR AlphaFoldDB; R7JB53; -.
DR STRING; 1262913.BN646_01374; -.
DR MEROPS; M41.A17; -.
DR Proteomes; UP000018199; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR PANTHER; PTHR43655:SF2; SD01613P; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000313|EMBL:CDE60823.1};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:CDE60823.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018199}.
FT DOMAIN 2..98
FT /note="ATPase AAA-type core"
FT /evidence="ECO:0000259|Pfam:PF00004"
FT DOMAIN 121..164
FT /note="AAA ATPase AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17862"
FT DOMAIN 180..362
FT /note="Peptidase M41"
FT /evidence="ECO:0000259|Pfam:PF01434"
FT REGION 373..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 46143 MW; 1DB81491D0FBEF0F CRC64;
MFVGVGASRV RDLFRQAKEK APCIVFIDEI DAVGRARGKN ANMNSNDERE NTLNQLLTEM
DGFGSNSGVI ILAATNRADI LDKALLRAGR FDRQIHVELP DLNERKEIFG VHLRPIKIDD
SVDAELLARQ TPGFSGADIA NVCNEAALIA ARNNKKFVQK EDFMNAVDRI VGGLEKRTTV
MTETERKRIA IHEAGHATIS WKLEHANPLV KVTIVPRGKA LGAAWYLPEE RPITTREEML
DEMCSTLGGR AAEELYSGQI SNGASNDLER VTKQAYAMVV YYGMSDKLPN INYYDSSGQE
WGFTKPYSES TARIIDEEVQ QIISEQYERA KKILAENAEG HNELANVLLE REVIYREDVE
HIFGKRPWAS RSEEILEKEN KDDKNDKKNV KEESPVSETS EEAPQTEEDK
//
