ID R7JMT6_9FIRM Unreviewed; 312 AA.
AC R7JMT6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Probable cell division protein WhiA {ECO:0000256|HAMAP-Rule:MF_01420};
GN Name=whiA {ECO:0000256|HAMAP-Rule:MF_01420};
GN ORFNames=BN630_00840 {ECO:0000313|EMBL:CDE64986.1};
OS Blautia sp. CAG:37.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=1262757 {ECO:0000313|EMBL:CDE64986.1, ECO:0000313|Proteomes:UP000018204};
RN [1] {ECO:0000313|EMBL:CDE64986.1, ECO:0000313|Proteomes:UP000018204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:37 {ECO:0000313|Proteomes:UP000018204};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in cell division and chromosome segregation.
CC {ECO:0000256|HAMAP-Rule:MF_01420}.
CC -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000256|HAMAP-
CC Rule:MF_01420}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE64986.1}.
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DR EMBL; CBJJ010000037; CDE64986.1; -; Genomic_DNA.
DR AlphaFoldDB; R7JMT6; -.
DR Proteomes; UP000018204; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR HAMAP; MF_01420; HTH_type_WhiA; 1.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR InterPro; IPR003802; Sporulation_regulator_WhiA.
DR InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR NCBIfam; TIGR00647; DNA_bind_WhiA; 1.
DR PANTHER; PTHR37307; CELL DIVISION PROTEIN WHIA-RELATED; 1.
DR PANTHER; PTHR37307:SF1; CELL DIVISION PROTEIN WHIA-RELATED; 1.
DR Pfam; PF02650; HTH_WhiA; 1.
DR Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR Pfam; PF10298; WhiA_N; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_01420};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_01420};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01420}; Reference proteome {ECO:0000313|Proteomes:UP000018204}.
FT DOMAIN 123..167
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
SQ SEQUENCE 312 AA; 35494 MW; 424D22CEFBC88662 CRC64;
MSFSSEVKEE LSRHLPTARH CQIAETAAIL SLCGQISEKD GTIRIQTENA YVARKYFTLL
KKTFNIEAEL AVKLNQKENT YLIRVNDREE TRQILQAVKL HETDRQLTMP IPAVVVQRQC
CKRAFLRGAF LASGSISDPN RFYHLEIVCP DAPRAEQVQE LLKSFGIDAR IVLRKNHHVV
YMKEGAQIVE MLGIMEANIA LMNLENVRIL KEMRGSVNRK VNCETANINK TVSAAIRQIE
DIRYIEETTG FSSLPEPLEQ MARLRLQYPE ASLLELGKML TPVVGKSGVN HRLRKLKEIA
EDLRRKQGGE VL
//
