ID R7MCV9_9CLOT Unreviewed; 1022 AA.
AC R7MCV9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN790_00427 {ECO:0000313|EMBL:CDE97602.1};
OS Clostridium sp. CAG:813.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262843 {ECO:0000313|EMBL:CDE97602.1, ECO:0000313|Proteomes:UP000018381};
RN [1] {ECO:0000313|EMBL:CDE97602.1, ECO:0000313|Proteomes:UP000018381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:813 {ECO:0000313|Proteomes:UP000018381};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE97602.1}.
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DR EMBL; CBKA010000027; CDE97602.1; -; Genomic_DNA.
DR AlphaFoldDB; R7MCV9; -.
DR Proteomes; UP000018381; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 7..334
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 335..639
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1022 AA; 118656 MW; 251BB37DC8266859 CRC64;
MAEKFVIKPN EKQQEAIDIL KGQVMLLAGP GTGKTFTVIN RIEKMLSDGV EPSSILCLTF
SDAAASEMRQ RLIKKMGVKA SSVDIYTYHS FCNDIIKEYP SQFEMSGDVR LITDTEKISL
MKECIDEANL EYFVPARADK YFNTKNFISH VEKLKTKRVT KDEYLDCINT NPSLMPRYKE
VESEIYEREQ AGKTQNKGRY AELEKIKTNI EKAKELWTLY ELYSQKMLNN NLIDFSDMIN
FVLNAFEEDE AFLGEVSNKY TYFLVDEYQD TNDLQNKIIF NLVDSNEEKN VFVVGDDDQI
IYGFQGAKSD NIENFLTKYP QTKVICLNEN NRSTQTILDF SNLVVSQDLN RLENNDYFKN
TYNISKKLTA KNPKIIEKDK KINRLQFAET IQEFNYIVDE IKNLVDSEDC PTNDKNEKDL
SQIAIIAKKR AELQTFSELL KAKNIPCQID EGKSIFSIRS TILVYFYLKA MNNHVLSSDK
LFGLMLSEPF KLDIQDYNKI LMEQRLLKND GLNDFISLMR TLKDWKNPQI ISEFLETFDD
LKAYATTNTL RNTVIEVVNR TGILEYFYKC QKNRIENLSG IRKLISEAGN YQKIDETRGL
SDFVTYLDDC LKNEIDICLD KDSSVQNAVQ LMTYHGSKGR EFEYVYLPNL ISSSWENFRM
PGEYKLITDE VYDKDFAQAK KDSELLKLLF VGITRAKHSL TLSFADNNEN KAQQITKYLS
EFSNYDFNSQ QFECDSDDLT KEFVRSISTE VFDNRKAFQN EIRERVKSIV LSPSRVNDYL
TCPRKFFYLK VLGIDVEEAD WDNANFGSVI HSILERAVKI AKEKGDYPDI KFALDEFHTG
MDNSRFSELA KKEKFIKLGE KLLMNYYPYF LQIPATRVEN VEFSFYGVSV GDDLVTGKID
RIEKNSDGTY SLYDYKTGRP TSEKQISPDG EKKNYYNQLC FYKYAYEKLT GNKVSQVGII
YVEDHARSVY KTLTDLDMEY IENLIKDTYS NIKSLKFNPI KEDKQGVCKN CVYKHLCKLD
LI
//
