ID   R7MHJ8_9FIRM            Unreviewed;       227 AA.
AC   R7MHJ8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Vitamin B12 dependent methionine synthase activation domain {ECO:0000313|EMBL:CDF00574.1};
GN   ORFNames=BN739_00570 {ECO:0000313|EMBL:CDF00574.1};
OS   Ruminococcus sp. CAG:624.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1262965 {ECO:0000313|EMBL:CDF00574.1, ECO:0000313|Proteomes:UP000017977};
RN   [1] {ECO:0000313|EMBL:CDF00574.1, ECO:0000313|Proteomes:UP000017977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:624 {ECO:0000313|Proteomes:UP000017977};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDF00574.1}.
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DR   EMBL; CBKC010000030; CDF00574.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7MHJ8; -.
DR   STRING; 1262965.BN739_00570; -.
DR   Proteomes; UP000017977; Unassembled WGS sequence.
DR   GO; GO:0008705; F:methionine synthase activity; IEA:InterPro.
DR   Gene3D; 3.40.109.40; -; 1.
DR   InterPro; IPR017342; S-AdoMet-dep_Met_synth_prd.
DR   InterPro; IPR004223; VitB12-dep_Met_synth_activ_dom.
DR   InterPro; IPR037010; VitB12-dep_Met_synth_activ_sf.
DR   Pfam; PF02965; Met_synt_B12; 1.
DR   PIRSF; PIRSF037984; Met_synth_TM0269_prd; 1.
DR   SUPFAM; SSF56507; Methionine synthase activation domain-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017977}.
FT   DOMAIN          120..188
FT                   /note="AdoMet activation"
FT                   /evidence="ECO:0000259|Pfam:PF02965"
SQ   SEQUENCE   227 AA;  25285 MW;  D66EAB9C911994E7 CRC64;
     MKITEIDKNQ ALRYMGHKGE VPPVISEMVE KCEKLVLNEI RPLYVYRESP LEFTDKGVLL
     SDGNILLTGN DIKKHLEGCD KAIVFAATLS ASADLLIRRL ETSDMAEALA TDALCSAAIE
     QVCDKAEHEI FQVQKYEFRT WRFSAGYGDL PISLQKSLTE YLNAQRRIGL TVTDNFLMIP
     RKSVTAIIGV SDTPLKKHGT AGCSACNLRD RCNFADSGRC SNLRTLH
//