ID   R7NG94_9FIRM            Unreviewed;       449 AA.
AC   R7NG94;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN   ORFNames=BN774_01511 {ECO:0000313|EMBL:CDF11157.1};
OS   Eubacterium sp. CAG:76.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262892 {ECO:0000313|EMBL:CDF11157.1, ECO:0000313|Proteomes:UP000018156};
RN   [1] {ECO:0000313|EMBL:CDF11157.1, ECO:0000313|Proteomes:UP000018156}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:76 {ECO:0000313|Proteomes:UP000018156};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC       {ECO:0000256|ARBA:ARBA00005163}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDF11157.1}.
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DR   EMBL; CBKG010000121; CDF11157.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7NG94; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000018156; Unassembled WGS sequence.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06113; citrate_synt_like_1_2; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT   ACT_SITE        326
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        385
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   449 AA;  51146 MW;  312E432574E1CA01 CRC64;
     MENINDYSKK QADMCIDNDS IPKALYTDYG VKKGLRDENG QGVLTGLTNI SSVRAFDVID
     GEKVPCDGEL LYRGYDVTKL VKGAGDKRFI FEESAYLLLF GELPDATQLE EFRHIIANCM
     ELPTNFTRDV IMKAPSADIM NSMTRSILTL ASYDDRKDDL SIENVLRQSI QLISTFPMLA
     VYGYHAYNHY ERDDSMYIHR PDKELSLAEN FLRMLRPDMK YTPLETHVLD IALLLHMEHG
     GGNNSSFTTR VVTSSGSDTY SAIAAAMSSL KGRKHGGANL MVMNMMEDIR AHIKDYHDEE
     EIEHYLDKIL NKEAFDKKGL IYGMGHAVYS LSDPRERVFK GFVEQLANAK GRAEDMALYN
     NIERIAPMLI AKERKIFKGV SPNVDFYSGF VYDMLDIPKE LYTPLFAIAR IVGWSAHRIE
     ELVTTDKIIR PAYKSLVTKR EYVDRSHRD
//