ID R7QLL9_CHOCR Unreviewed; 448 AA.
AC R7QLL9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=CHC_T00008307001 {ECO:0000313|EMBL:CDF38673.1};
OS Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa).
OC Eukaryota; Rhodophyta; Florideophyceae; Rhodymeniophycidae; Gigartinales;
OC Gigartinaceae; Chondrus.
OX NCBI_TaxID=2769 {ECO:0000313|EMBL:CDF38673.1, ECO:0000313|Proteomes:UP000012073};
RN [1] {ECO:0000313|Proteomes:UP000012073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Stackhouse {ECO:0000313|Proteomes:UP000012073};
RX PubMed=23503846; DOI=10.1073/pnas.1221259110;
RA Collen J., Porcel B., Carre W., Ball S.G., Chaparro C., Tonon T.,
RA Barbeyron T., Michel G., Noel B., Valentin K., Elias M., Artiguenave F.,
RA Arun A., Aury J.M., Barbosa-Neto J.F., Bothwell J.H., Bouget F.Y.,
RA Brillet L., Cabello-Hurtado F., Capella-Gutierrez S., Charrier B.,
RA Cladiere L., Cock J.M., Coelho S.M., Colleoni C., Czjzek M., Da Silva C.,
RA Delage L., Denoeud F., Deschamps P., Dittami S.M., Gabaldon T.,
RA Gachon C.M., Groisillier A., Herve C., Jabbari K., Katinka M., Kloareg B.,
RA Kowalczyk N., Labadie K., Leblanc C., Lopez P.J., McLachlan D.H.,
RA Meslet-Cladiere L., Moustafa A., Nehr Z., Nyvall Collen P., Panaud O.,
RA Partensky F., Poulain J., Rensing S.A., Rousvoal S., Samson G.,
RA Symeonidi A., Weissenbach J., Zambounis A., Wincker P., Boyen C.;
RT "Genome structure and metabolic features in the red seaweed Chondrus
RT crispus shed light on evolution of the Archaeplastida.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:5247-5252(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; HG001951; CDF38673.1; -; Genomic_DNA.
DR RefSeq; XP_005718578.1; XM_005718521.1.
DR AlphaFoldDB; R7QLL9; -.
DR STRING; 2769.R7QLL9; -.
DR EnsemblPlants; CDF38673; CDF38673; CHC_T00008307001.
DR GeneID; 17326295; -.
DR Gramene; CDF38673; CDF38673; CHC_T00008307001.
DR KEGG; ccp:CHC_T00008307001; -.
DR OMA; EWEKSDM; -.
DR OrthoDB; 3639304at2759; -.
DR PhylomeDB; R7QLL9; -.
DR Proteomes; UP000012073; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CDF38673.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000012073}.
FT DOMAIN 80..414
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 448 AA; 48736 MW; 638E3140F37E3A9B CRC64;
MRPVFKNLEY CSSQPDMSML HRLPLLVRRL PPTMPSSPRT VCTSSLQLTH GVASTGLLVP
DSSLLHPVLE QWVPPNISTR TLLLNRPRAL HALSEPMCSA LHARLHTLAN LGTRCVVLAA
HGTPARAFCA GGDVRAVYDH GAAGRFEDGD DLFRIEFRMN SLLARMRPAA VAILDGIVMG
GGAGLSVHGK YRVATSNTVF AMPECAIALS PDVGASYFLS RLEQPGLGMY LALTGARLKG
GQVKEAGLAT HFVSPEGVHE LISRLQASEL PDEAAIGAVL KEFEVDTGPD GQLDGLDVIR
RSFTRDSVAS ILGALNDIVK DGTEQESTFA SSTVALIRKQ CPTSLKIAFQ AQTRGASLSV
DDCLRMEFRI VTRCLRRDDF YTGVKSALVT KDRNPIWNPA NIDDVSDEAV EKFFDPLEND
LRILELELGE AQSEEVAKPF RPRLNSRL
//
