ID   R7R1U4_9FIRM            Unreviewed;       532 AA.
AC   R7R1U4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Metallo-beta-lactamase family protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN450_01268 {ECO:0000313|EMBL:CDF44634.1};
OS   Roseburia sp. CAG:100.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262940 {ECO:0000313|EMBL:CDF44634.1, ECO:0000313|Proteomes:UP000018092};
RN   [1] {ECO:0000313|EMBL:CDF44634.1, ECO:0000313|Proteomes:UP000018092}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:100 {ECO:0000313|Proteomes:UP000018092};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDF44634.1}.
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DR   EMBL; CBKV010000083; CDF44634.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7R1U4; -.
DR   Proteomes; UP000018092; Unassembled WGS sequence.
DR   CDD; cd16295; TTHA0252-CPSF-like_MBL-fold; 1.
DR   Gene3D; 3.40.50.10890; -; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR022712; Beta_Casp.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11203:SF37; INTEGRATOR COMPLEX SUBUNIT 11; 1.
DR   Pfam; PF10996; Beta-Casp; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   SMART; SM01027; Beta-Casp; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018092}.
FT   DOMAIN          13..240
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   DOMAIN          252..381
FT                   /note="Beta-Casp"
FT                   /evidence="ECO:0000259|SMART:SM01027"
SQ   SEQUENCE   532 AA;  59343 MW;  531DED8E6A6324D2 CRC64;
     MKLTFVGADH QVTGSCHYLQ ACGRNILVDC GMQQGINPYE CCDIPVEEAK LDYVFLTHAH
     VDHSGNLPLL YAKGFRGRIF TTEASADLCS IMLRDCAHIQ MQEAEWKNRK AKRHAGMEAV
     EPAYTMEDAD GIIRRLVPCA YDSMIEICEG ISIRFTDIGH LLGSASIEVW LTEGEETRKI
     VFSGDIGNVD QPLIKDPIPT KDADYVVMES TYGDRFHDQN RLDYVAELSA VIRETFAKGG
     NVVIPSFAVG RTQEMLYFLR KIKADNLVPE FPKFEVYVDS PLAVEATGIF QKNIYSCFDE
     EAMELVRNGI NPLAFPGLRL AITSDESKQI NFDEKPKVII SASGMCEAGR IRHHLKHNLW
     RPECTILFVG YQAVGTLGRA LIEGATDVKL FGESVDVRAQ IRQLAGLSGH ADKNGLIAWL
     EAFENKPKRV FIVHGEDSVC NLFTECLKIE HGQKAYAPYS GTRFDLITDA IEYEAAPVPV
     KKRTNVVSDV FTRLLAAGQR LIAVIHKNEG SANKDLAKFA DQINALCDKW DR
//