ID R7RZE2_STEHR Unreviewed; 433 AA.
AC R7RZE2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
GN ORFNames=STEHIDRAFT_126372 {ECO:0000313|EMBL:EIM79682.1};
OS Stereum hirsutum (strain FP-91666) (White-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Russulales; Stereaceae; Stereum.
OX NCBI_TaxID=721885 {ECO:0000313|EMBL:EIM79682.1, ECO:0000313|Proteomes:UP000053927};
RN [1] {ECO:0000313|Proteomes:UP000053927}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FP-91666 {ECO:0000313|Proteomes:UP000053927};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
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DR EMBL; JH687402; EIM79682.1; -; Genomic_DNA.
DR RefSeq; XP_007311253.1; XM_007311191.1.
DR AlphaFoldDB; R7RZE2; -.
DR GeneID; 18797747; -.
DR KEGG; shs:STEHIDRAFT_126372; -.
DR eggNOG; KOG2733; Eukaryota.
DR OMA; KRPVQMH; -.
DR OrthoDB; 5479972at2759; -.
DR Proteomes; UP000053927; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053927};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 281..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..146
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 433 AA; 47267 MW; E31A41ACC56D1CFB CRC64;
MTTPTERATN AYDFVIFGAT GFTAGFVLEE IAQHVRLPPD FTWALAGRNE QSLLKIAEKY
SSNSSVPQPD IIIADVKTEK GLLEMARSAK LVLNCVGPYR YLGEPVVRAC IEGRADYLDL
CGEPEFIERM SLEYHEKAVE AGVTILHAAA FDSVPCDLGV LEMKRALLER GATPSSIEAF
FRVNTESSFA IHYATYEAAV LGFGSGGTEL GRIRKALAKV RPKPSAIGSF KAKFGALGVK
KDPRTEGWII RYFFADPSVV RLSQSLDIHV GGSSVLPPVH FAAYLVIQST WALALLVFYF
TIFQFLTGRA WGRNLLLKYP KVFTAGLASK EGPTSAQLAG ASFTETFYAK GYSNTSSITG
PPDVTLVGRI TGPEPGYVAT PKLFVKCALT MLRSRNGHRM INGVLTPAVL FRDVRLLDEM
KAEGWLGWNV VDG
//
