ID R7S5H2_PUNST Unreviewed; 1042 AA.
AC R7S5H2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=DUF221-domain-containing protein {ECO:0000313|EMBL:EIN04656.1};
GN ORFNames=PUNSTDRAFT_55382 {ECO:0000313|EMBL:EIN04656.1};
OS Punctularia strigosozonata (strain HHB-11173) (White-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Corticiales; Punctulariaceae; Punctularia.
OX NCBI_TaxID=741275 {ECO:0000313|EMBL:EIN04656.1, ECO:0000313|Proteomes:UP000054196};
RN [1] {ECO:0000313|Proteomes:UP000054196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB-11173 SS5 {ECO:0000313|Proteomes:UP000054196};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; JH687553; EIN04656.1; -; Genomic_DNA.
DR RefSeq; XP_007388049.1; XM_007387987.1.
DR AlphaFoldDB; R7S5H2; -.
DR GeneID; 18883975; -.
DR KEGG; psq:PUNSTDRAFT_55382; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_002458_3_0_1; -.
DR OMA; QGIGMFP; -.
DR OrthoDB; 366603at2759; -.
DR Proteomes; UP000054196; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF83; CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054196};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..223
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 245..434
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 446..720
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 18..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 117038 MW; 7D7C0613CFB6B2CA CRC64;
MDPILKLFFR FLLDDPDGPD DPGQDEPGGA PPGSPPTHTF EGPWFQTQMV LASSIGITSF
LIFSYARTRW PLLFAPRTKL KGFSPHESHA QQGFFGWILP TIRTSEFTVL QIVGLDAAVL
LNFYKMSFYL FSLCSLFAAA ILMPINLKSN ISNGGDDADD DWPIGPGPNI SSVRFPFISA
APTNGTQPGR DWLDLISDAN SYLSVHLLFT YLFTLLSLYF IYKNYKRFIR ARQLFSLELV
HSIPARTVMI TQLPAHLRGE RALAEYFEGM DLAVESVSVC REVGSLKRLI DARTRALLKL
EKAWVDYVGN PSTVESYDPA ESVAPPLVDV ADGVADAEAQ RGRVVVPHRP RPTIRVGWFG
PKVDALEYLE TKFKEADEAV RKKRRTGKFK ATQTAFVTFE KMSSAQIAVQ TATASTPFQC
KTHLAPEPRD IVWSSMSLPQ STINLRDWVV VAGMGLLLFT WIFPITALST LLSYKEIQKV
MPWLARLIER NDNIRAVVQN SLPSVAMVSL NALLPFLLEA LTYMQGFRAR SWVEYSLMKK
YFLFLLTTVV FIFLLASTYW QLVRELANSP ARIPEKLAQD LSKGRARHFF LSYVILQGMG
LMPLQLLNLG VAIPYVVRRA LFTRTPRDFA ELNAPPMINY GVVYPQAMLI FIITLLYSVI
QPLILFFGAL YFGVAYVVYK YKLLFVFYKP YESQGQAWPI TFVRLIWGVV MFLVFMTGIF
TLRKAWIISS LLLPLLGGTV VWSWYISKEF EPLSKYVSLS SVNEVQRGED SAEVLRLKAG
HPVTWSQSNL HRRRYAQHDE TLYVAPEDDR TDYSQPPMAN WYPGVLNTGK RRYGHPALNG
VLPQPWLPLK KGQTLVNGDR PRTNKIGKAA DDAVVLTLRR RPSTLRRASR RASRTASRAL
LTRVDSAPAE GAASTSAAPA DGAEDTLANP WGEDGAESHL RRSSTMPNPL HHRLSFDDAS
GVIMLPEGEW LDQDESSDSD DDLPSPGHAS TSGSREPSQA NDVQFPATET QTLLPRSPSK
RYGTYYHHPE RRRTQTMPGT FA
//
