ID R7SPL8_DICSQ Unreviewed; 515 AA.
AC R7SPL8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 22-FEB-2023, entry version 49.
DE SubName: Full=Creatinase/aminopeptidase {ECO:0000313|EMBL:EJF56927.1};
GN ORFNames=DICSQDRAFT_183502 {ECO:0000313|EMBL:EJF56927.1};
OS Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Dichomitus.
OX NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF56927.1, ECO:0000313|Proteomes:UP000053319};
RN [1] {ECO:0000313|EMBL:EJF56927.1, ECO:0000313|Proteomes:UP000053319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF56927.1,
RC ECO:0000313|Proteomes:UP000053319};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; JH719460; EJF56927.1; -; Genomic_DNA.
DR RefSeq; XP_007370308.1; XM_007370246.1.
DR AlphaFoldDB; R7SPL8; -.
DR GeneID; 18841353; -.
DR KEGG; dsq:DICSQDRAFT_183502; -.
DR HOGENOM; CLU_017266_1_2_1; -.
DR OMA; ESKHINH; -.
DR OrthoDB; 1377484at2759; -.
DR Proteomes; UP000053319; Unassembled WGS sequence.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1.
DR PANTHER; PTHR43226:SF1; XAA-PRO DIPEPTIDASE; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:EJF56927.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:EJF56927.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053319}.
FT DOMAIN 6..128
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 515 AA; 56939 MW; 366B28C98CF1EA61 CRC64;
MTHKKYPASQ HVLKTFTKLI ELLPAVEQNK ESNFFYLTGC KVPSSYALLT FQSGTSLANK
PPSHLFIPKA ELADLMWSVP PPSIAEATAT HDVTSIDHPA ALPEAIQEQI KAFPGAIVHI
LPTSSLFPKI PAQYTAAFLA GNVNVTEDYL LTAVHRARLT KDAAEIELIR RANQISSRAH
ETVMRVLGQG IRGQIKRGKG AGTERPLLPG EWLIEREYEA EALFVASCRR EGAEHQAYLP
IVAASTRAST LHYCCNDREF SWGPVGPHDH HNTNDLAHDH ERVLNPQVLL IDAGCEWSCY
AADITRTMPV GNGGRFTPEA RAIYELVLEM QRLSMEALKP GLHWDAVQLL SHRTLVRGFQ
KLGIFRSPES PGSGSWNSEE AILASGISAA FFPHGLGHSL GLDVHDVPSA SKPDVNPTIE
HLQLGHESFY TYLRLRLPLE EGMVVTVEPG CYFSPHLIAP VRDSKHIDQE VLKRYESVGG
VRIEDVVLIT KDGYENLTTV RSDPDWLEQV CAGEI
//
