ID R7SS76_DICSQ Unreviewed; 1474 AA.
AC R7SS76;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=CNH-domain-containing protein {ECO:0000313|EMBL:EJF59044.1};
GN ORFNames=DICSQDRAFT_156433 {ECO:0000313|EMBL:EJF59044.1};
OS Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Dichomitus.
OX NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF59044.1, ECO:0000313|Proteomes:UP000053319};
RN [1] {ECO:0000313|EMBL:EJF59044.1, ECO:0000313|Proteomes:UP000053319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF59044.1,
RC ECO:0000313|Proteomes:UP000053319};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
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DR EMBL; JH719428; EJF59044.1; -; Genomic_DNA.
DR RefSeq; XP_007368164.1; XM_007368102.1.
DR GeneID; 18837624; -.
DR KEGG; dsq:DICSQDRAFT_156433; -.
DR HOGENOM; CLU_001251_5_0_1; -.
DR OMA; CFRQKII; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000053319; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053319}.
FT DOMAIN 721..908
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 943..1072
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1094..1389
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1474 AA; 164325 MW; 17781FBE77598BF2 CRC64;
MDRPMGPRRP DKRNAAYESI FGRPSTQHHQ LTPGPPPPAQ FQQQFPQQQP SSQPYPYYPQ
YSSQLDRRTS TASFRPYQQQ QVPPNTFRQS YYPNSSPSPP NPVSQQQGYQ PPAYSQHQYG
YAGSLAPPSI ASRARSIGSA PGVIAPLPEE PPDPALEALT RSGLTPAQAY QAQVYMNNGP
MGQQQSWLQQ QQHPPPPQHN QPQPPSPSPA RSAPTPASPS RPDGPRGPRP QSVQTMPPAL
DKFPELRINI EADDGRLGLD FINETSFGNG DAYGSKGGPE ATPPSDPTTE DDSSELPYSK
PYHTSTPNSV RSRVSVASGV GGSVDLNSSV GHSHQSSSRP YPLQLDTAIA SAQAAGVSIS
PASSTLVDEP TQMVHVGPAH AGPSGRRSSE SARTLPGQFQ FQRNRSITDR SHSMSAAMTP
HIRAMIEAGR TGRPPVPSSV GPGRDSPHPR PRRTPIVYPA LLSRVAEAFK ERIQLSDRLK
DGLTYKDAFD GREAVDTIAY IIKTTDRNLA LLLGRALDAQ KFFHAVTYDH RLRDSSHDLY
QFRTKLPSPF VSGELANIHN APHEHGEILK ALETPQPLIG GAEPSDGNKD KESPSPSAED
DSEKKDGSRP GSPTPSVTPA SPTAGRPRAG SIASDDVPLP TGVFTLLTDC YSPTCTRDQL
CYSIACPRRL EQQARLNMKP QRELKKQISK ESLGELVEAG TLWIHTVPAE VVASVSDAEK
KRQEAINEVI YTERDFVRDM EYLRDLWMKP LKESDIIPEP RRQDFIEQVF WNIHDIIAVN
TRLRDALNKR QKSYAVVEQI GDVLLEAVPH FHPFVSYGAH QLYGKYEFEK EKSSNPAFAR
FVEATERRPE SRKLELNGYL TKPTTRLARY PLLLEAVLKH TPEDNPDKTA LPKAIEIVRE
FLKAVNAETG KAENRFNLLQ LDQQLVFRPG EQVDLRLKEE GRELIYKGAL KKRGNAQGDS
GDLMVFLFDH ALLMVKPKSK VEQYKVYRRP IPLELLLVSA PDDYAVAKPM NARQKQLIKN
SPHAPVVPVK DAKGGFSITF VHLGRKYYQI TLWASTYVSQ RKWVEHIQKQ QDAMRERSNV
FETVTINEGF FVGVNRVNCA APFYQGRKAV YGTDDGVYLS NLMERNREPV KVLALKDVAQ
LDVLEEYQLL IVLSERQVIT FPLDALDPMD PLAGLKRAKR IASHISFFKA GVCLGKTLVC
VVKSSPLSST IKTLEPIDQQ VRGRAKPTFK KLLQGGNDTL RVFKEFYIPL QSSSIHFLKT
KLCVGCTNGF EIVDLETLDT QGLLDPADAS LEFVHKRENL KPLAIYRIDN EFLLCYDEFA
FYVNKTGWRS RKDFMVYWEG SPTGFALHYP YVLAFEPTFV EIRHVETGSM SQIIQGNNLR
CLFADTPPST TNSSSNYYSP YQVQQLGYGG YNPYAQDSRT SMSSNGYGSP GQYPNPYMPR
PPLGDGRDEI LMVSDDRVMR LQMTQTARAA LHLM
//
