ID R7T2D3_DICSQ Unreviewed; 579 AA.
AC R7T2D3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=FAD/NAD(P)-binding domain-containing protein {ECO:0000313|EMBL:EJF62215.1};
GN ORFNames=DICSQDRAFT_161099 {ECO:0000313|EMBL:EJF62215.1};
OS Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Dichomitus.
OX NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF62215.1, ECO:0000313|Proteomes:UP000053319};
RN [1] {ECO:0000313|EMBL:EJF62215.1, ECO:0000313|Proteomes:UP000053319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF62215.1,
RC ECO:0000313|Proteomes:UP000053319};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SIMILARITY: Belongs to the FMO family. {ECO:0000256|ARBA:ARBA00009183}.
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DR EMBL; JH719406; EJF62215.1; -; Genomic_DNA.
DR RefSeq; XP_007364927.1; XM_007364865.1.
DR AlphaFoldDB; R7T2D3; -.
DR GeneID; 18838056; -.
DR KEGG; dsq:DICSQDRAFT_161099; -.
DR HOGENOM; CLU_035533_0_0_1; -.
DR OMA; ENCYEGL; -.
DR OrthoDB; 1434032at2759; -.
DR Proteomes; UP000053319; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR000960; Flavin_mOase.
DR PANTHER; PTHR23023; DIMETHYLANILINE MONOOXYGENASE; 1.
DR PANTHER; PTHR23023:SF226; FLAVIN-CONTAINING MONOOXYGENASE; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00370; FMOXYGENASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053319};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..235
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 579 AA; 63660 MW; DA4F69AC7F1E098A CRC64;
MQQRRDGRDN HPRNGAIAVV GAGLAGLITA YTLIRDGFED VQVLTRDAHV GGNWAQGKTY
PGLYLNSVHG EYCVSALSMP PPASDCGRTS GDEVGAYLET FGSKFLKDKI QYGVEVVRIE
RPPSGTGWRV RVHHRKTGLT EVRHYRRVVL CTGGQSAPRF PPNMSPESAA ASGFKGIVFH
SADFGSKLSD LLASVPPAVS SAEPDSPTVL VVGGGKSAQD IAAYLANEGR KVTIVCPNFD
AFLAASEPLP NWVRKSRLLS LFSPHIYLRT WLERFVHTTW LGKKLFDLFW TGLVSASFKA
AGIPLGSPLR NTVSPFWHDR VNDEGVPRPN GFHALTLSGK ISVVSPAYAT SFGTDGESVL
LDNGVSIRAS AIVLATGYHS SWSAMFDEEA QEELGLKPHL AYQSQPYRWD YLTLRDPPPL
NPVAERWSSS IYRGIVPAKN IERRDFAVNG AIFSTHFGYM LEVGSHWISS YFLEDDMRLP
ATSEVALEET ERQAAWLRHR YPQVAPTANS SHTSNIGFWG WPQVADDLLE DMGLKVMRSG
GTWLTWPFRV VSVKEIAGLK EERDARRALK GTSKYAGSP
//
