ID R7T3W2_CAPTE Unreviewed; 103 AA.
AC R7T3W2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Histone H4 {ECO:0000256|ARBA:ARBA00020836, ECO:0000256|RuleBase:RU000528};
GN ORFNames=CAPTEDRAFT_103539 {ECO:0000313|EMBL:ELU04479.1},
GN CAPTEDRAFT_104225 {ECO:0000313|EMBL:ELU11087.1}, CAPTEDRAFT_113150
GN {ECO:0000313|EMBL:ELT87493.1}, CAPTEDRAFT_128650
GN {ECO:0000313|EMBL:ELU02043.1}, CAPTEDRAFT_137816
GN {ECO:0000313|EMBL:ELU17957.1}, CAPTEDRAFT_143645
GN {ECO:0000313|EMBL:ELT91937.1}, CAPTEDRAFT_146051
GN {ECO:0000313|EMBL:ELU02625.1}, CAPTEDRAFT_157638
GN {ECO:0000313|EMBL:ELT95146.1}, CAPTEDRAFT_178734
GN {ECO:0000313|EMBL:ELT91189.1}, CAPTEDRAFT_184022
GN {ECO:0000313|EMBL:ELT97810.1}, CAPTEDRAFT_203393
GN {ECO:0000313|EMBL:ELU15445.1}, CAPTEDRAFT_213178
GN {ECO:0000313|EMBL:ELU17535.1}, CAPTEDRAFT_213300
GN {ECO:0000313|EMBL:ELU08392.1}, CAPTEDRAFT_90262
GN {ECO:0000313|EMBL:ELU12647.1}, CAPTEDRAFT_90469
GN {ECO:0000313|EMBL:ELU09857.1}, CAPTEDRAFT_96390
GN {ECO:0000313|EMBL:ELT87527.1}, CAPTEDRAFT_97484
GN {ECO:0000313|EMBL:ELT99662.1}, CAPTEDRAFT_97619
GN {ECO:0000313|EMBL:ELU04789.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT87527.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT87527.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT87527.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP103539}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC DNA into chromatin, limiting DNA accessibility to the cellular
CC machineries which require DNA as a template. Histones thereby play a
CC central role in transcription regulation, DNA repair, DNA replication
CC and chromosomal stability. DNA accessibility is regulated via a complex
CC set of post-translational modifications of histones, also called
CC histone code, and nucleosome remodeling.
CC {ECO:0000256|ARBA:ARBA00002001, ECO:0000256|RuleBase:RU000528}.
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|ARBA:ARBA00011538, ECO:0000256|RuleBase:RU000528}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the histone H4 family.
CC {ECO:0000256|ARBA:ARBA00006564, ECO:0000256|RuleBase:RU000528}.
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DR EMBL; AMQN01000360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01000650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01001089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01002459; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01002977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01003621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01005361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01008740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01010743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01016855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01023844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01025261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01034178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01035327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01040717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01041424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01044771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01048052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB312312; ELT87493.1; -; Genomic_DNA.
DR EMBL; KB312282; ELT87527.1; -; Genomic_DNA.
DR EMBL; KB310616; ELT91189.1; -; Genomic_DNA.
DR EMBL; KB310317; ELT91937.1; -; Genomic_DNA.
DR EMBL; KB309217; ELT95146.1; -; Genomic_DNA.
DR EMBL; KB308469; ELT97810.1; -; Genomic_DNA.
DR EMBL; KB306668; ELT99662.1; -; Genomic_DNA.
DR EMBL; KB304436; ELU02043.1; -; Genomic_DNA.
DR EMBL; KB303858; ELU02625.1; -; Genomic_DNA.
DR EMBL; KB302273; ELU04479.1; -; Genomic_DNA.
DR EMBL; KB302106; ELU04789.1; -; Genomic_DNA.
DR EMBL; KB299137; ELU08392.1; -; Genomic_DNA.
DR EMBL; KB297873; ELU09857.1; -; Genomic_DNA.
DR EMBL; KB296980; ELU11087.1; -; Genomic_DNA.
DR EMBL; KB295796; ELU12647.1; -; Genomic_DNA.
DR EMBL; KB293808; ELU15445.1; -; Genomic_DNA.
DR EMBL; KB292479; ELU17535.1; -; Genomic_DNA.
DR EMBL; KB292207; ELU17957.1; -; Genomic_DNA.
DR AlphaFoldDB; R7T3W2; -.
DR SMR; R7T3W2; -.
DR STRING; 283909.R7T3W2; -.
DR EnsemblMetazoa; CapteT103539; CapteP103539; CapteG103539.
DR EnsemblMetazoa; CapteT104225; CapteP104225; CapteG104225.
DR EnsemblMetazoa; CapteT113150; CapteP113150; CapteG113150.
DR EnsemblMetazoa; CapteT128650; CapteP128650; CapteG128650.
DR EnsemblMetazoa; CapteT137816; CapteP137816; CapteG137816.
DR EnsemblMetazoa; CapteT143645; CapteP143645; CapteG143645.
DR EnsemblMetazoa; CapteT146051; CapteP146051; CapteG146051.
DR EnsemblMetazoa; CapteT157638; CapteP157638; CapteG157638.
DR EnsemblMetazoa; CapteT178734; CapteP178734; CapteG178734.
DR EnsemblMetazoa; CapteT184022; CapteP184022; CapteG184022.
DR EnsemblMetazoa; CapteT203393; CapteP203393; CapteG203393.
DR EnsemblMetazoa; CapteT213178; CapteP213178; CapteG213178.
DR EnsemblMetazoa; CapteT213300; CapteP213300; CapteG213300.
DR EnsemblMetazoa; CapteT90262; CapteP90262; CapteG90262.
DR EnsemblMetazoa; CapteT90469; CapteP90469; CapteG90469.
DR EnsemblMetazoa; CapteT96390; CapteP96390; CapteG96390.
DR EnsemblMetazoa; CapteT97484; CapteP97484; CapteG97484.
DR EnsemblMetazoa; CapteT97619; CapteP97619; CapteG97619.
DR HOGENOM; CLU_109117_2_3_1; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR CDD; cd00076; H4; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR001951; Histone_H4.
DR InterPro; IPR019809; Histone_H4_CS.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10484; HISTONE H4; 1.
DR PANTHER; PTHR10484:SF0; HISTONE H4; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR PRINTS; PR00623; HISTONEH4.
DR SMART; SM00417; H4; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR PROSITE; PS00047; HISTONE_H4; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU000528};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000528};
KW Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW ECO:0000256|RuleBase:RU000528};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000528};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760}.
FT DOMAIN 28..93
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 103 AA; 11367 MW; A9E5DFD3F8B97598 CRC64;
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGG
//
