ID R7T491_CAPTE Unreviewed; 771 AA.
AC R7T491;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 13-SEP-2023, entry version 48.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN ORFNames=CAPTEDRAFT_180635 {ECO:0000313|EMBL:ELT87658.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT87658.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT87658.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT87658.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP180635}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; AMQN01015798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB312231; ELT87658.1; -; Genomic_DNA.
DR AlphaFoldDB; R7T491; -.
DR STRING; 283909.R7T491; -.
DR EnsemblMetazoa; CapteT180635; CapteP180635; CapteG180635.
DR HOGENOM; CLU_004747_6_1_1; -.
DR OMA; IREWDRY; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF169; CULLIN-1; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 416..644
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 57..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 89748 MW; C1352451EE2710ED CRC64;
MATMRSNPHG LKQIGLDQIW DDLRYGIEHM YRRQSMPKTR YMELYTHVYN YCTSVHQPGQ
SGQSSRGQGN RKRNQPTGGA QFVGWELYKK LRDFLENYLV DVLRDGQELM GESVLEYYTR
RWEDYQFSSK VLNGVCAYLN RHWVRRECEE GRKGIYEIYS LALLTWRDHL FRALHNQVTN
AVLKLIERER NGETINTRLV SGVINCYVEL GLNEEDPIAK GPTLNVYKEH FENSFLDDTE
SFYNRESSEF LRQNPVTEYM KKAESRLMEE TRRVQVYLHE STHDHVAHVC EKVLIEKHLE
SFHSEFQNLL NDDKNDDLGR MYQLVSRIKD GLGELKTLLE THICSQGLTA VERCGDSAVN
EPKVYVQTVL NVHKKYNALV MTAFNNDAGF VAALDKACGK FINNNAVTRM AAASSKSPEL
LARYCDLLLK KSSKNPEEAE LEDTLNQVMI VFKYIEDKDV FQKFYSKMLA KRLVQHMSAS
DDAEASMISK LKQACGFEYT SKLQRMFQDI GVSKDLNEQF KRHLQQTTDS NDIDFSIQVL
SSGSWPFQKS CSFTLPTELE RSFQRFTSFY SGQHSGRKLN WLYHMSKGEL VTNCFKNKYT
LQASTFQMAV LLQYNSADDF SVQQLQESTQ IKMDILLQVL QILLKSKLLV TEDDEADLQP
TAVLALYHQY KYKKLRVNIN VPMKTDMRQE QEATHKHIEE DRKWLIQAAI VRIMKMRKVL
KHQQLLGEVL NQLSSRFKPK VPIIKKCIDI LIEKEYLERV DGQKDTYSYL A
//
