ID R7TB20_CAPTE Unreviewed; 2447 AA.
AC R7TB20;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=KASH domain-containing protein {ECO:0000259|PROSITE:PS51049};
GN ORFNames=CAPTEDRAFT_175674 {ECO:0000313|EMBL:ELT88687.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT88687.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT88687.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT88687.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP175674}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQN01003398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB311733; ELT88687.1; -; Genomic_DNA.
DR STRING; 283909.R7TB20; -.
DR EnsemblMetazoa; CapteT175674; CapteP175674; CapteG175674.
DR HOGENOM; CLU_000034_1_1_1; -.
DR OMA; THTEMGR; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR CDD; cd00176; SPEC; 7.
DR Gene3D; 1.20.58.60; -; 13.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524:SF5; KLARSICHT PROTEIN; 1.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 7.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 19.
DR SUPFAM; SSF46966; Spectrin repeat; 17.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..2396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TRANSMEM 2390..2415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 2418..2447
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 2388..2447
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 1915..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1956..1980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2334..2356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..167
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 191..256
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 759..793
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2447 AA; 281935 MW; BE75477E672AD680 CRC64;
MYRFLPRTST DGSGDKASRV QQSLLELEDC WRKLESQVDD KQARLEAALR FQQLYQDTMV
NVSSWLDDIE QRLCNTPMDR NIEQHLKENE VRSGELMQCT LHCAHHPQSL QMELASIQQE
LDHMTRSSQK LLAEAGEDSK DMINQSVLDL NDRVAHLEGR AKDQQDKISQ RNVSWREFQV
GIYGHHSVIL ISSSQDNVRG LQSKLAAARQ QYASLATSLL PLGDQLKEAE VLEGLIKEYE
SQLQQLQGTG DAMMADDPSV TLPLELNALN AHWQDLHQLA SEHKYTLDQA IAMQSQYERM
LGEFTEYLET AQTKLDSDDL SAKDCAHLQE QHSAHKAFFA NLESHRTLLE ALQQKVDPAT
RQRLLATHTS LVNSSHVVQD KAAFRGQQLD RLCSQWTDFQ AIYSDVNSWL ERLKRQAPSQ
MRNTDALEEI RSKIWNFHSM QSALQERKAD VFHVVDKGRQ ILQAVSCLLL DEELQGFSER
WAQLNSEVDS SLKRLRSVLD QLEQFDRDMG TMDSWMEAAQ NRTVSVVGVH ERDSQNITAL
KSQMDAFLDF RKEVENQQPL KTKVVTLGNQ LLHSRPNDFV IQDKLDSMEK RWMDLVKELP
DNEEQLHKAQ MELLPSRQAL NEMLLWLEGI EATIREDSGM IPMSLMDAQV LLRKYRDLKI
DMANRQLTID FVNQSGSQVS QPELENVPAL GSSVRAERAE FAERLGQMNK RYLSICSDVD
DKLKRVEIQQ MKWEEYEKGV STLNNWFDNQ ESAFKKFQHT GHEASVEQAI KDCKDLENQL
KEKETEIDAI KLLGTGLMDP HPPTSGDRPV TTTVNALNER WRGLDGQLYR VSANLEEALS
QWKTYTAALS KVNQHLMDAE FALARYGTAS GDLKNFKANI KKLQKLQSDI GASRRDVEKV
SKAADALLGS CDPVAAQSLN KQVALLQAKW QEVYDALDDQ VSSNEHLSIQ WQDYEKEYER
CRLWVEGKEE EVSLLIVEGT SSNDALQRTK DMKRDLENFA PKLTTLSQLS DQLTPCMDNA
TIIHITARES SLQQRLNTMQ QSLNRQQKML EEDLNRHARF DLAFKNVDQF LSQAEVILHT
ADPVSTADAA DIRDRLEEFR VLSNKFTEKK SDLETVNLIG YRLSLGEADS QSMRQLNQKW
YQLSSETSDR YKHMQSHLLL QQDFSQKCEE WMLFLAQVEK DLTAEVAGNY EALLEQQQAY
EAFHQHLHTR QQILHSIIAE GTQMIANGDV EDKAGFERKL LLLDEQWRSV VNRAAQRKAI
LQSQVELWRR YNETLSQLKG KMNDVSESLA SLEVRSAPLQ RLKLMLNSCK TGQREVALSE
PLYHKLHEMG KLLKPTVDSE SRSRIASDLS SCEKQWLDII ASLDSRKESL RDILNLWDNT
ESGMEDSLAW LKGIRHEVTR DLPLTYDDLV MALQQCQEFE NSFANAADKR GQLRQQHHQL
RTCVSAEDTG ILQQRLLLLD TQWQEILHQV HLRKQRVQER LGGWSAFSLR YKELLSTMSN
LETKIASSKE VSIEDLLFKL QNDYREELRT MDRDRQWLCD EGERLKRASS DVRASDIEFK
IARVEEKWSC LEEKAQLRLL KLQETLKTVQ QLEHNMGKLR SWLVYVEHEL TSPIVYQHCD
FLEIQRKLTE QQEMQTDIER HSSGVASVLN LCEVLPHDTD ACPTDVERRA IESAKASLEK
RWRSICQLSM ERRIQIEETW RQWEKFHADH QRLSDFLAEM DGLLVSPRTE SATFDQLRAE
LRKFETHKRR LHESIKQLDS LNRHYRHLAR EGRTDVAGEL RQMVLTTNDF WDELSQRTAT
IMRRLKHTTN VVDDFRATRE GLLIWLGGLQ TQMADVSCNP GSYDVKLEQL RPIQHDLQQN
SHRLEYIDKV STYLMQKCEA SDAVQIQREV EEFHVEVENA VSRLASLKES FELGEGSPQR
KLPLKKKSKK KKKRTTTYRE TSAAVQPLNW DEYGLDLDID SSPETNANGQ LKAQPDGQDR
WRSDLRRQVA PKKERLIRLE AYLQELQHAL GELLPHLDSS EQVLRAPTPL GAEAEGMNVK
YVSYFQKVSA CQDYVDTVQT LERRLREETG VSKVMSVDPQ VKEVLDRWKV IETEALEKDQ
RLLRRQQQWT QLKADLRRLL AWLEEAEGVQ SRQTTVPTEI RQLEAAVRRQ REFTLQINNR
KPVVLSVNLL CKELVALGTP ESRDLWQRLS AMNQRWDKVC ANADVWQKEL QIAMMQCRDF
TETVQDLMLW LEEKGAEIYA LEPVDLQTSL SVLHGKCTKF KILKHELEAA QPRIASLQDT
AVSLDDKGGE LTAAKERLLL VASQHKSLLK ICLTYLTRLN NTLEGGDLST LRSMDESKRY
KPPALSPRSA TSPFSTRQVG ESSFDIESDI GECSQRETRS LLMRRRRSRL VARVCCAALP
FHMLMLLLLG VACLVPMTED DYSCVLANNF RKSLDPMLRH TDGPPPF
//
