ID R7THQ5_CAPTE Unreviewed; 1662 AA.
AC R7THQ5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136};
DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117};
DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820};
DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031};
GN ORFNames=CAPTEDRAFT_225337 {ECO:0000313|EMBL:ELT93318.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT93318.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT93318.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT93318.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP225337}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AMQN01012823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB309782; ELT93318.1; -; Genomic_DNA.
DR STRING; 283909.R7THQ5; -.
DR EnsemblMetazoa; CapteT225337; CapteP225337; CapteG225337.
DR HOGENOM; CLU_242110_0_0_1; -.
DR OMA; DEEPGQC; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd11236; Sema_plexin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 2.
DR Pfam; PF18020; TIG_2; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1662
FT /note="Hepatocyte growth factor receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008787027"
FT TRANSMEM 1245..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..477
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 1358..1622
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1391
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1662 AA; 184131 MW; EAD34365AA7FC51C CRC64;
MDWSWLLAVW LVSLQQGSYA SQILKTFPSE SGVTLRNLVY SSVTNELFVG GVNRIYKLDD
NLSLKTSLTT GPREDSVQCP PNPSDSCCTG SDTQTCSVVR KRSNATTMAL AIDTSNNKLI
ACSDLYYGSC HKVDMSSLRI VERVFVPVVS NDPDLLPIIF ISDGMDGEGN LYVASPRSHL
GMDQYTRRVP LLATRSLSSF EYARDASFKD LRNTDNYEYF EVLYKYAFDY KGYNYFMSVQ
RESLTSRVLV TKISRVCQLD EYYNSYIEIP LSCSSSNTGY NVLTSAYLGK PGSILARMTG
AKTTDSVIFA TFTKDGDPSK SAVCIYPMPV VMRAFLSALQ RCFSGNNVVV KVGPEHLVQP
QQCTAMSVDV TGKYCGTVSS NNPIEGKTDL SHFALYRING EFLTAIRVKA IDIHTVIYLA
TESGKILKLV PETLSSGRVY QEYPLNSGPV LPHGMKFDKT MDSLYVLTAN KVLKVLVSEC
DKHVSCESCL GAGDPHCGWC FSQNMCTDQD ECPDSENFSW FDYSATCPSV STIDPGQISF
SSFQQTAISL ILPLFPNNVE EGVVKCVLKG SHPPQEVPAK AQTWNSNGKA SGTEVLCENF
KAISALPDGK DHVELDLEIR VMNSPWASTV VMVYDCGRLS SCTDCANTTM PCDWCVEHHS
CSAKDPPSCA GGIVITSGKK PRTRLATGFT TLYGLEMCPQ IDNLPSISEI KAPSGVAKSF
TVRAFNLQSV HTEMQCRYST PSQTIVTTAE LRDVSVNVKD VICKERVLSY LRDSPFEKFP
LDVMWDGHPI DNPSNIQIVV YKCSQLASNC GHCLLLDPSY DCGWCENGCS MQRDCPTGLL
ERNATCPDPQ ITSFSPRGGP VNGGTILTIQ GTNLGKTVSD IKNSVNVAGV LCSVNASMYI
APETVVCKTG PASAAHNGTI TIRVKDKFTA NSPTKFIYAD PIVTGFKPKQ GPMSGGTNVT
IFGHQLDLGS NFTVSMNNVR LQILEKHENR LVVRTPPQDR NYLRPISLLL DNSEENLLSP
SFQFREDPDI DDVQPELAIL SGGNILTVIG KNLDIIQKPY IQVTVPDGQQ RQALCETLLA
SRMHCPTPDL SEYANVPTPG RAKRDFQYNP FVPSFPMKVR YGFVMDGVET LLNLPGDSQL
TYYEDPYFFP FSGADRTKPY SKDMDLEISG EKLLVFEIFN KEAIILVGGV SCPVTRVDKV
RIICKPPTSP RIMDNGLATV VAKLGNVKTE LGKLNYAAGA NVSTALILGI VLGLLLPLVI
IAIIIFICWR RRNSRKNRNK VVMPPPNSVP NNYQQNRGSA ELDGAAAEEA IPLKANEEGY
LDDAPIGEKT NWADLLNRIE NPKIRKAVAD VMISKDRLEL GELIGKGHFS CVYAGTLLDE
SYENPSKVAI KTLQSNDFDR HSVENFLKEG VIMKNFRHAH VLQLLGVVVG PSNEPMVVLP
FMANGDLRSY VKDKKKNFTA RQLLGLAQQV AEGMAYLSSL NCVHRDLAAR NCMIDEENIV
RVADFGLTRD LYERDYYSSK DRKAKLPIKW MALESLEDFV FTNRTDVWSY GVLMWELMTR
GVTPYPDVDV FDIRTYLASG RRLRKPKYCP DNVYKIMLDC WHEIPERRPN FADLVNRLEI
LLNPPKKRQP STEPATSEPM YMNISKSDSV EYLNPVSPPA ET
//
