ID R7U1H6_CAPTE Unreviewed; 1057 AA.
AC R7U1H6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Phosphatidylinositol-4,5-bisphosphate 3-kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_183615 {ECO:0000313|EMBL:ELT99799.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT99799.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT99799.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT99799.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP183615}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00879}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQN01009879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB306460; ELT99799.1; -; Genomic_DNA.
DR AlphaFoldDB; R7U1H6; -.
DR STRING; 283909.R7U1H6; -.
DR EnsemblMetazoa; CapteT183615; CapteP183615; CapteG183615.
DR HOGENOM; CLU_002191_1_1_1; -.
DR OMA; WSEWLNY; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05165; PI3Kc_I; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR003113; PI3K_ABD.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR000341; PI3K_Ras-bd_dom.
DR InterPro; IPR015433; PI_Kinase.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10048:SF111; PHOSPHATIDYLINOSITOL 3-KINASE AGE-1; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF02192; PI3K_p85B; 1.
DR Pfam; PF00794; PI3K_rbd; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00143; PI3K_p85B; 1.
DR SMART; SM00144; PI3K_rbd; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51544; PI3K_ABD; 1.
DR PROSITE; PS51546; PI3K_RBD; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 14..103
FT /note="PI3K-ABD"
FT /evidence="ECO:0000259|PROSITE:PS51544"
FT DOMAIN 188..288
FT /note="PI3K-RBD"
FT /evidence="ECO:0000259|PROSITE:PS51546"
FT DOMAIN 328..483
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 513..690
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 757..1042
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1057 AA; 122335 MW; 561ABBBBAB92C372 CRC64;
MPPSSGELWG HHLMPSQVDV DCLLPNGIII SLPCYRDANL GTIKFELWKE AKKYPLFSQL
SDASSYIFVS ITQDAEREEF YDETRRLCDL RLFQPILKVV EPKGNREEKM LNYDIGIAIG
MSVNEFNDNK DLEIMTFRRR VLDVCKMAVE ERDSRGNLSQ ARYVYPPDIH HSAQLPPHIN
ERIEKEGKGK IMICIWVVSA SDRQKYTVGV SHMATPEEVI AEAIRRRTRL MNMSPEQQRR
CIVEYQDSYI LKVCGCELFL LEKYPVSQFK YMRTCISRSR IPQLMLMSKE GVFSSLPKNI
FTIPAYVMKG VSAFQDINKQ NTTSLWNMDA MLKIKINSAM YVNVKEKGEI YVKTGIYHGT
ESLCPIKDTA RVESSNPKWN QWLEYDLYLP DIPRCARLCL ALCCVSKKQK KKQVHYALAW
GNINLLDFNN RLLCEKTTLR LWPVPQGQED MLNPIGVPGP CPNGDSPCVE IEFHRFGMPV
SYPTEAQIDE YANWLSSRNR NQAHVQGSTT APPLMNEPLS KTEQDQLQEI IRRDPLSELS
EQDKELLWKS RHACIPIPGS LPKLLQAVKW YSREDVVQVY VLLREWPIVS TETALELLYC
TFTDLTVRRF AVKCLEEGLT DDQLSQFLLQ LVQVLKFEPY FDNYLTRFLL RRALLSQRIG
HFFFWHLKSE MHQANIRQRF GLILEAYCRG CGAYLKSLCR QVEALDKLAK LSDSVKMERE
ETQMKVLCSQ VQQADYMEAL QHFPSPLNNS YILGDLIIED CEVKHSKKKP LQLVWQNPDA
MSELLFTDFK ILFKNGDDLR QDMLTLQVIG IMDSIWQGEG LDLRLIPYGC LATGPNMGMI
EVVRNARTVL KILSQDIRSA MMVRTKELHS WIKEKNKGDR YQQAIELFTM SCAGYCVATF
ILGIGDRHPS NIMVTEEGQV FHIDFGHFLD HRKKKFGINR ERVPFVLTED FIRVIARGQD
NPIKSQEFAD FMELCGKAYL SLRKHSNVFI TLFTMMLSCG IPELQSLDDI GYLRKTFVVE
KSEQEALEYF QKRFNEAYGG AWTTKLDWFF HWVKHGN
//