ID R7U2K2_CAPTE Unreviewed; 5119 AA.
AC R7U2K2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=CAPTEDRAFT_220835 {ECO:0000313|EMBL:ELU00225.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU00225.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU00225.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU00225.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP220835}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AMQN01001860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB306105; ELU00225.1; -; Genomic_DNA.
DR STRING; 283909.R7U2K2; -.
DR EnsemblMetazoa; CapteT220835; CapteP220835; CapteG220835.
DR HOGENOM; CLU_000038_9_1_1; -.
DR OMA; LQVMSVT; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF395; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760}.
FT DOMAIN 2162..2338
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2477..2639
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2813..2962
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 502..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1881..1903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2336..2382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3584..3627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3760..3797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3418..3452
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4098..4150
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1881..1898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2347..2380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3594..3619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3760..3780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5119 AA; 581501 MW; ED033631C0D25049 CRC64;
MDERHWWIAG KIQESFRIGG FDNPTLLEDF MCEASTMAII NSFLNPGGQC RLFFYCDQVD
ANALSTRQLH TTANLASLKD INLEVITILY FLRQNLDAAV DVGHMERDIF CGELKGNTIT
NLNSLLSDIY VPLMKVQKNW GSSTGDAQNN LVHNLDKVMN SLTESTASLN ASKHIMLKQP
ENVVGNEFKQ HRLAALDHTI ITEYEDLVTD WMNTIESILH DTSDERFLDP NAGPLSELER
WKRRQRMLTS ITEQLKSKEC KGVIGVLITA KSRLLKRWKS VDSGITDAMN ETKDKVRYLE
SLRRHFDLLY ADATPAVIIN TALPGFINTV KQMDSVSRFY ARQGFLGLLL TKIKRNGSTE
VAHEGLFTRL KACLMLHTYY RDSIRSLRDA LGVSHSLSHA NSISSLAGPV SAGGRRTNRI
SISSASPSKK AMSQASSDLE GHGVPIADEE TVLGHLDSFC SRIKQILDII NTFAQFDKML
KNTSALPRPR NDDLVFYEKD EKANDTAADE APTKPQVPTI EGMSNSLDVI DEDEERLIEK
ADRDRRQRDV SDFANIDEAY DAMGISGGLT KKDVEILKEY YPYDQKDEGP SIYSIIQGKI
SRMIHGMIGS ATTSTMLDVE SKDKGRFEEV YSSFIQMVMD IEKFFAAYLN ALFMRKIKTH
EALDLMMLFS CISQRPGVRM VISEKFVEIF NWYESDLEEV QCIYERHKDD PLLARNAPPV
AGAIGWSRNL LSRIEEPMKI FRENKAVSNL RDYSRIVKIY NRLATALVTF ESLWFTHWKQ
SIEQARSGLY ATLFILHPET REIMVNVDSK VLELMQEAKW LKRMNIQIPE SASQIVQKES
RFKGYHDHLQ LCLNEYKSVC AAIPEALLIL FKPHIDACLQ NFQPGLSTLA WNSMNIDPFL
HQIHTGTAKL KFLVDRVNSI MANKVERAIE NIRQMIFFDH KLAFSRSWPP EKFIEMMGLS
IGDQSKELTQ YIHNIEVGIK ECANILTGRK MNTWANTLSI LRIAKFWKDK ALSRTTEERA
HFEAEKIRGM EELKRKAERA ELLFGAKLAS GNISSTKLEE SLIAPKSYEE EETMVNELLD
NYRHQIYAAI LLATTRSLVT LAESSGCDGE VIRAASVLSF DKNSSHRLLS DPTSRVASAI
SDKSRPVSVL SLLSNMTWTT EKSSEVTHLQ FEVNVKFAIP NIVLEPNLDA IQTALNFVAR
SLLQVPRSVK WTGDKDLGSK FFELVQSDEV VDEIMMQISQ VVEDLQSVVK QHINHFGIYD
FLWQDDMYGN YYEFIEHDPG KAAIHREVER LLKIERKVLS IPKSLPVGPI CLMTSPVQDA
LHGFAMAWKN QYASVLHDEA KRKLDAAVLY RANVRQRLEL PVLSLDQLNS TLHLLEEVRD
MENKIDDIYL PIETHYAKLR EFELRLPRSE VEEVDQLRDH WQELLSLADG VCLTLLKEKR
GAFEQELDKQ VKNFVVEVIQ FRNAFDAQGP AVPGIPPSEA VKRLQDFLQR YSLYEAKRKT
LDSVSKLFGI PCKPFPELDK TGEELELLGL LYGLFQKFIR FDDQFRDTLW AEVELQVATH
EVESFWDECL ALPSKLKDWD AYNDMKNSIQ LYRDLIPLLH KLASKEIRNR HWLQVMAVTG
SSFQLEAAVF KLSHLLDIGL ITHRPEIEEI CRSASRELEL EVKLRMTEEE WTEQVLNFEP
YKKRGPMYLD KTSTERLLEQ LEDAQALLAQ MLTSRYVGPL REEAASWAEK LKEVGQVLDQ
WLEVQDLWQY LEAVFSNETS LSKELPQEAK RFARIDKGWT KMMKRAYDTR NVLQCCYGED
VPKGVVLRHI YQELEICFKS LIGYLDVKRR AFPRFFVVSD QTLLAMLSRP HALDSVRPHF
KSLFSAISDV TLERQQLSAS ELELQGSPHS SSPRRNPFSP AVESPVKIDK RLTQVLNLNR
SQASLYVSTI LPSENINEES ITMEATAVMS SEGEFLPLID KVPLTGGVEV WLENLRTSVK
STLHEQLLSI CYDISNNVPC DEWPNKYTTQ VCRLGLLYYW TRECEVGITE IKFDRKALSN
LSRKFGSTMN KLPLAVSRSS KGDEKLIALY RLRVEQLLTN SIFLRDSIDA MATRRLRENT
DFEWRRNLRL YVHDVDDQPT PCLYMLENCF PYGCEFYGAQ PTIALTAFAD KCFLSLTSTI
SSFQGAMVSG ESGVGKSETV KGYAQIMGQF LMVFQCSPKA DSSSLSKMVE GMAMDGCWGC
FDDIETLNPE GVSVLIDHVQ SILDALRSAA KHCTFGDGQE ASHSVAKQPD LGIVLKAKCS
SYGLKSPHVL ANRLRTVAEL SRDQLSDDQH HELSVEAICG VLRRVVLRRR VLKEEKSFDK
KPSDMQESRS NSVLSTSNHN LQQQQSVANI SGQKTRKAGT PNPLSAAAKI EHGLVGQLLM
DMIGPRLTPE NLAIFRQIVK DIFSGLPESP PGSAIMSANR SLLDVETALE NTAAESGLVV
HKAWKDKCMQ LFAISQVHQG IILAGPPGSG KSTIVQTLVD ALCTAPRGLS RGSARSQVQD
GSEANHKLQK IFPAVVDDLS LVFGHLNQNH DWVDGIFTSV WKKASRNQST TWICLDGPLH
SSWVDNFSSI LDASKMLHLA NGDQLPLSNN IKLLFETDDI NEASPALIAR CGILFVDKDV
VGWRPIAKAW LDNRTQQELH VLQRAFDKTV DPVAHYVLDE CKPRMRLSEV GMFCTTINLL
SAMLADNIEI GGELHIERLY LFCLMWTFGG MLETKDRKGF NELLSSLSTA LPDDDRDICF
FDYYVDESGE WDPWQSRVPE ATNPEHLNLL GEVFVDTVDT IRTRLLMELA CASSQNVLLV
GAPGSGKTSL INDFLSSQDY QQRVTTKLVS SGSSTAKQLQ HFIESNIHHR QGFVYGAKEN
KHLQLFLDDL NLPQPDEHGV QRSNERHFTV LSLPVPSGDS LTSVVHGVLE ASMLHGGHAP
LESDLHQAVL KASCRLLTDL RSVLKCSPLP GRYHYLFTLR DFVNCFQCLR RLPDESRADE
KLVASLWKHE TERIIKDQLC RYTDIAWFEE TMTETLELCF PKVASNLFPH FVTFPIDART
YQRPVTTISS RKEVKVMLQP VESLQELHGC LQTHLNRYNE EFGNVHLDIM LSENIIFHII
KMHRVICYHH SGSFLVVGPI GSHLGTLIQL ALHVASIPLH AIDSSKENNF LDGLRSAGRD
LINPLYMDAI NSLLVSGEYP HLFTNDEMEG LLQAIGPAMK REHSNFTVDP AKYFVSRVRT
NLHIVICLPP THPLLKIAPN QYPGLISGCQ LIWMCDWTKE SLLGEAAYFL NKSTLTKDCE
NDLSENVMAI MANIHSFVLQ DCRQCKWAGD TNEELTLNEV KVNEKKKELL KVQTRTLPNR
PFSKAIMLES IKLKHKQLET PSTSELFVGP TSYKRFMKTF KCIYTKKAKE RTQVVGTLKK
ALSTLDQTRD DAQKMRQDIR TITLKFENAR EKTGHLLSDL TLKATALEKL RAQLGMSTSL
SAFLQLNEMS DEEEEDTELL KEDERDEYDD EFDRMRAANL KTRLIAAKDE HTEAVKTVLH
WRGRVDRQCV ERLKAFQNPP MLVGHVLEMV MTLIGKRLPS QRLETKADNY PTKEEQSGRF
TSSSSSTKFT GSVKKSKSVD KSSTGAERFD RAQWKSMQQM LNDTAKFVDI MHNVAWEDGL
PDDVRAAVES YLARSRDGLL GVTGEGSLLD NAQEKERGLI AQRRSPSPDN TRGISIAAAK
YASEDAATLV NYTIAIVEYT RLCGPLKAAM ERRHELEREI EENDRLQREQ GQQEGEKEGE
AEVEKAEEEE LTEKDLPRLQ EEVQDLQAHF DAAVVEKHSL EMELTSMKER LKAATNMIGS
LKPQEASWRQ YVEEHISNDM LVANSLAAAA FLTYCSAMNA DCRSRLGEFF ITICEHHNLP
LPPKKLFKNM SLMDFLEKPL MVYELRKLNL PTTPLMLENS ALLMQGDTTM AWPLLCDPVS
HVLSVLRSYL NNQGLVEVSY THLRSQFDTC LAEGLPLLIT DVDVHEFIHD QRFRSIIYLR
NKFVSGQNPF KMKVGEHEVE CQPHFRMYLH TTSLPHEVPP ELAAHVGLLY FHQTREDVEE
QLLDRFMRRE KMRLDEEKRT LLMERMTNSK NLEELEQEMV QCLSSEVRLL NDLSATKKLA
ELKKQHEETE ESQCRVDTAE QTLSRARESF RVIAKQGAVC FDTMQYMREI NAVYKVSFVQ
MLELFDQAVS HSDRAAVKAV VDRLMNLFFV STTRFLSERD KQIYCLLLAL EVEDAEGRVG
RGEREYLISP SLGSVTMTAL GCSAAQDSKF VQAKKPFDWM NEDQFSNLQI LAIHYEWFQD
MFDRMPKDGR ETQWRNLCES DQPEMQPLPD RMDDQYTLLQ RMLVIRAVRS DRLNQVSVLF
INNILDKKLL GEGNGLDLTG ALRQAAPKTP LLMLYTTEKE AAERAVLEFA ARKQVDVIPV
SLSGPTQAIE KVARKSLAKA MATGCWLLLQ NGHSQVHLLN SLELMFSEQE TIDPNFRCWI
TAEAKADLPT TILQSCVKIM IDKPRTIRDQ LVRTFSSIDA ETLRHSSKVD WLPLLHNICY
LHGALKLRSR FGRGGFNKHA DFTQIGLSTL VECINLAKDE FMDNLSVLAP DGSALPRSTS
WSGLRFMVAE VFCGNFVEDP LDQQSLTAMV EYWLSSNACK KDFELPRIKY KIPAVFFNQN
VRQTQLVQAL ESTTPFFLES AEACNLHPSS ETLMGDDQYI FTRLNKIYDA MPSSQSLTHK
LFPRPPSPFD AHEICPWTLN TWKIILDGSN TRNIPHLEDY LLRVHVDNRP QICPPMANIS
AHSNNPQIVH MGVFASASFA TLKMKKEVEL WEVCHLMAPK VPRAYSKDYI TERIKKVGGF
TSFNMFIMKE LDIMYQLITD IKTSLQAIKA ACELTNMGEM LTPTLLGIAD DLYHLRIPHH
WCRLAGNTAP PPNYALGTWL TDLANRCQHF ERILVLGREK MPAYWLGAFT YPRGLLALLK
QDCYRHHPQD RSGAFDQYVF QTEVTARDKD HIRDPPAEGM FIFGIYLWGC AWEKTTGDLI
DTPPRHACAA LPVIHLTCWP QADKPILQDA SKASEIYACP VYQSRIAPRR PILELDLSHS
GVPSTRWSLR GLSATIRPY
//
