ID R7U439_CAPTE Unreviewed; 1965 AA.
AC R7U439;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
DE Flags: Fragment;
GN ORFNames=CAPTEDRAFT_167900 {ECO:0000313|EMBL:ELU01115.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU01115.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU01115.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU01115.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP167900}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQN01001758; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB305378; ELU01115.1; -; Genomic_DNA.
DR STRING; 283909.R7U439; -.
DR EnsemblMetazoa; CapteT167900; CapteP167900; CapteG167900.
DR HOGENOM; CLU_001676_0_0_1; -.
DR OMA; SSMVTHE; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760}.
FT DOMAIN 1736..1945
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 326..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1573..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..935
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1379..1394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1965
FT /evidence="ECO:0000313|EMBL:ELU01115.1"
SQ SEQUENCE 1965 AA; 219691 MW; 79B9F3BD9D97B272 CRC64;
MFGRKGHGDV KKSAVKVLDP KKDTVTRLKH LKVVLDTYDI ADSKAFFEQN YSYIYYIFYD
VFTNVESDLK QRANKTHREE LDFVLFIFEK ILTLLPELIH KRWQYHSIGR VMKKMLHPGN
SLKVRREGMR LFIVWYQILM DNAMKECHDT YRCLVPKLGN TDTSQTDIFT VKNAVNSKRK
VCAVEITPLL LPQSGDKQPE NMTKYMLESL LTFMVSEVNK IEWPNHKMPE FSFNFLFNKF
KEFYLGNIFP DLRETNIYSP CLDLPEARNL DQVDGVNSGT SALCQEAVVK WIANFTHTVQ
RRNSTLQARP DNKLPASLDL QADSTVDADD QTDPAEPPVP GSNASTLSHV SSYTERDSGA
SSVCSDDHSI SEYEIVKRIL YSNRANINMV HEVFRQAFLF PFHHGGAGAV RRVIAVYKEW
LQDETRPVFM QEPGEESVSN TDSPSKANPS SPEATQAGLQ QVLQVFITNS ANVFLLESPV
DAKPGRESQA QYVDMCKRVL NIYRYMVMNH SLSLGTWEQL LLVLLRITSG VLSTTPPMYK
EKSLSGRLAQ PIFQTLIVTW IKANLNVQVS QSLWDHFLNV LSSLTAWVEL IREWAKTMDT
LTRVLARQVY NLDLNDLPLD RLSEQKEKRG RRGVKPPSQG SPRIRKRTFS RGWSRHDAVE
SLKAQLNQAA GMAQRTPGIL IAEMGGRQRS RSGETSPLHQ SSNHLSVGTQ DNLGPSEKPL
VRSNSDSSLF IPDPADKRAD THRTHSEVLP PKSPDIEDGT SGDELASPPD YLVNSRKEST
ATILSESGFG YLRLEDAPVN HGLTSIAERL STEGKEEDGV FHDRATEPPG LGSVSTVTGD
TVSVASVESG VPYQILDQSQ EEGNDDISDK DLTLRASDWS TSSYNGFNNN DLSGETDSLS
ANSMAREGSA ERDTDSLSEL KKSVFKDSPT PDRESLQMDD VDAALQTTPD NAQVSQSSKN
NLSDSRSVLA GGYLLGWTPD VAVVLWRRML GALGNVNQIR DPSMHAHVYE YFCDLMEILL
KIRDNLAVTR DNQSSFPPPE YLPPQLMLTP WWFEALDLGP DYQAGHLLAC RLLCMAVRCR
GYNIPSAMQP YLLRFYRTLH YGLVHGNQEQ INVLIRHCGS NFFSKPLPGA TILVLDFVHA
ANTIASATSL KTAPRAEALG LLGSLLCLPD HMGPSPCLQP SAQDMDIMMC SDLKDHVVNI
LLKSGRKEIN PTARCIAISS LAIYLYEELS HDIQHCKIKE AVGVLLATLR FSNKNVAMVS
SNMLALLGDH VNNLLNKHPD LPRRIIEEIA ATILTLLPST EYSDSEEDKK LLVSLMNCLL
EWCMKVPLEM LLEVPAAGQK TLLFKVFRVL NMVVLGSTSS LSARSTSPHQ NAELSVDNDA
ATGSSQSMPS TPQSLPHPDL LKADAMRVIP PRKGSPRRQR TPSPRRNLRD NYTIKLTART
VLSHLVNHLG HFPMGAGPAQ LYTAVKETHD QNMNDESDDL SPEIFNQPNV QFFVLNNSAI
VSCVEIPALM DMPGGGVTAG LTTGRTITRI IVRDPAGKFC WDNSVLYGPP KCRAGSFPAE
PTYNLPEDLD LIGQDKAEPD SNSANEEPCE ADPGSVSGVN RISSHLQIPH FSQSKQDADN
LNNMLQYIGH TSPECLLKPG EPLNIPAKAP DDLPDTTQTV AMEMLCLQKD DELQYYAAHK
RDSSLVARRL PPMEDRDTTS PFQLCRLFLN QLGFTQWEKR SQFDLLIKTD KLLREIKHLD
NQKGRDTHKV AVIYVGPGQE DKVSVLNNVK GSTLYENFVA GLGWEVDLEM HTGFLGGLQS
ANKSNGSSAP YYATSTKEVL FHVATRMPAE NDEDRMRKLR HLGNDEIQVV WSEHKRDYRR
GIIPTDFGDV LIIIYPLSNG LFRIHIDRKP EVPFFGPLFD GAMVDRHILP GLVRATAINA
SSALRMLKPY YRSFYEDRAY NLENIVLHHK QPTTFEDFSA QVFAP
//
