ID R7U6W8_CAPTE Unreviewed; 1952 AA.
AC R7U6W8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Echinoderm microtubule-associated protein-like 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_153818 {ECO:0000313|EMBL:ELT98865.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT98865.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT98865.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT98865.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP153818}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; AMQN01010290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB307500; ELT98865.1; -; Genomic_DNA.
DR STRING; 283909.R7U6W8; -.
DR EnsemblMetazoa; CapteT153818; CapteP153818; CapteG153818.
DR HOGENOM; CLU_001930_0_0_1; -.
DR OMA; WIFGYSA; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 13.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 8.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 3..47
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 233..263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 330..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 380..461
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 404..438
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 664..712
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1074..1116
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1230..1263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1341..1390
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1688..1719
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1760..1801
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1917..1952
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1268..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1952 AA; 215205 MW; 832B995CA62B3307 CRC64;
MSTKAAPKSQ LRLEWVYGYR GHQCRNNLAY TSSRELVYFV AGVAVVHSVR EHRQRFFLGH
DDDIISLALH PEKLLVATGQ VGKEPYICVW DSLSVSTVSI LKDGHQQGVG ALAFDSTGNR
LVSVGLDQHA TINVWDWRKG KIISTVRGHS DRVFDVQFHP YKENTLVSCG VKHIKFWTLS
GNTLSAKKGV FGKVGEIQTM LCLAFGSNES TYSGTLGGDV YVWKGSQLNR VIQGAHQGSI
FTLDFTDDGF ASGGKDGCVR LWDTDFKPIT KVDLTQSEDG YKGLSVRSVC WRGDRVLVGS
QDSEVFEIVV SEREKPKCLM QGHAEGELWA LASHPKKPVF ATGSDDHTVR LWNMQNKTIL
SKTTLDQPIR SCGFSPDGAS LAVGMADGSY MVLRTKDLQE IVHIKDRKEV IHELKYSPDG
TLLAVGSNDN FVDIYSVSQR YKRVGQCTGS SSFITHLDWS QDSKHIQTNS GAAERLFFKM
PGGKQLTNKD EIRGLHWATW TGVLGPEANG IWEKYTDTND INATDANFGS EVIVTGDDFG
LVKLFTFPSL KKGAKFRKYV GHSAHVTNCR FSSDRMHVVT TGGADHAVFQ WRFIAEGVGI
DEDIPDQHAY VDSNSEDSDS DMSDVAEIDS DIEAEKQKSY DRAVYKEDMA VLKKSAKQNV
ANGAKRNKAP SQGLKLQFVH GYRGYDCHNN LFYLQSGEIA YHVAGVGILY NRENHTQRFY
ANHTDDILSL CIHPLKDILA TGQVGRDPTI HVWDADNLKT LSILKGNHQR GVCAVDFSAD
GKRLASVGLD DNHCIVIWDW RKGEKLATTR GHKDKIFVIK WNPFEQQKLV TVGVKHIKFW
TQTGGGFTSN RGTFGNVAKV DSMMCVSYGK TPDLCYTGGG NGSIYVWVGL SLSKCIKAHD
GPCFAMHALD KGFVTGGKDG VVCLWDEQFE RSLKNYSIKR SALVAGTKGV LVNDNPAIRS
VVLGHGHILV GTKTSDLLEI NKEGAMNILV QGHREGEVWG LATHPRKLVS ATVSDDRTLR
VWDMSEHQMI NCKILKQPGR CVCFSPDGKA IAVGLKDGSF IVVNSDTLED IVQFHHRKQE
ISDIRFSPDP GKYLAVGSHD NMVDIYNVLS SKRVGTCKGS SSYITHIDWD SAGKLLMTNS
GAKEQLFFEA PRGKRQALRS AEVEKINWAS WTSVLGNTCE GVWPPGSDVT DVNTSSLSDD
RQVLATGDDF GFVKLFDYPV KGKHAKFKKY MGHSAHVTNV RWTANDTHLV SVGGGDTSVM
QWQHLGVGET RGDSDDSDTD SEEEGGYDSD VAREKSIDYS AKTYSNPIRS TSGVKPYQQD
YEDDDEKKTK VLAAEVAPSA EKSKRKRLTQ DLDLDLVMGF RGFDCRNNLQ YLNDGTDIVY
HAAGAGIVLN ISSAHQTFYT EHTDDIICLA VNEHPKFKGV IATGQIGATP EVNVWEASSK
RTLSIIKGHH RKGVCAVNFS CSGKLLLTVG LEDDHQVAVW RWQEGTKVAS SAGHSQRIFH
AAFRPDSDTQ FVTVGVKHIK FWSIAGGELV GKRGIINPLP DLPEAPRMQT LLSLAFGANH
VTYSGAMNGD VYVWKENILS RVVQRAHTGP IFSMYTTLRD GLVVTGAKER PSNAKDGGPV
KLWDQEMKRC RAFNLGLQES VDVVKSVCRS KGKILVGTKE SQFVELNEKT AETKMITCGH
GEGELWGLAT HPSTERFITA SEDGTVRMWD IVNKKMINSL KVGAARSAAI SPDGELAAVG
LKNGGFVVIT VATFRPWGQR RDRGDIINDI RFSPSGQYLA VGCQEGTVDF YDLRKGPQLQ
REGYCKGIQG FVAQMDFSAD SKYIKIGTGS YVSQIYSVPN GKEVKDKEML SKVTYASWTS
VLGSEVVGIW PRNAEKADVN CADVSHSGNA IATGDDYGLV KLFSFPSSEK YAPHKTFTGH
SAHVTNVRFT YSDRYLLSAG GDDCCIFVWK CK
//
