ID R7U9Z1_CAPTE Unreviewed; 1875 AA.
AC R7U9Z1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
GN ORFNames=CAPTEDRAFT_153639 {ECO:0000313|EMBL:ELU03185.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU03185.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU03185.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU03185.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP153639}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AMQN01008549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01008550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB303412; ELU03185.1; -; Genomic_DNA.
DR STRING; 283909.R7U9Z1; -.
DR EnsemblMetazoa; CapteT153639; CapteP153639; CapteG153639.
DR HOGENOM; CLU_001436_2_0_1; -.
DR OMA; CMEGKSH; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR CDD; cd11236; Sema_plexin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1206..1232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1468..1486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..446
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1585..1614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1234..1276
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1875 AA; 209387 MW; 553B313325956B69 CRC64;
MVIDRWTGKV YVGAVNRLYQ LSDTLGLEKS LTTGPKSDSP NCPPDISSEC DYPKKTTHSY
NKALLIDYKN SRLIACTNLY SGHCEKLLLS DLNIKDPISW QPMVPSDETS SVAMFIAPGY
PNPASTMTLY VGATRSTKGE TAFKDLLPSV CSRNLHDFQL VFDDNLVASK MEIEGQQRDT
FRVEYVYGFG SKDFSYFLTV QKESVASDNY ATRIVRVCQG DEKFNSYVEI SLECSHNGTD
YNILRAATVS HAGAELARNL VLSDIPPQTD MEHVLFAVFS KSRPSSRDPE PDSVVCVYPM
KDIRREFTET IIRCFEGQDN IGPSHFVLPQ QCLGVALEIT DSYCGEYDFN KPITGSQPIS
EEAVIRFPNA SLTAVSIAVT SNYTVALLGT DNGRLKKVVI ENKTSAFEYE TLVIDEGSPV
SADLALSDSG DHAYVMTEKK VTRVKLHDCG QYASCDSCLA SRDPFCGWCA LESKCSLRSE
CQDAAKHLHW LPYKDAQCTR ILHILPNQMQ VPEQVKQLRL TVQYLPLLSG SSRYLCTFSG
HGVTRTTQVS MEMTSVGANT TLQCETPIRH LLPPIPTGKD HIVMKLSLRR DEQDFVSTNF
TFFDCSLHES CTGCTDSNYP CTWCVRSHTC THNRESCGSD ILVTGKHVHG PSDRVGPGSC
PRIENSHTEI LVPSGKTFNV SVRAFNLQDF QSDFRCLIST KPRREVSALL SGNRIQCAAI
KFEYPGDTRA RIVPFQITWG PQRRPLDNPD AIKVVVYKCS AMASSCGRCL VLDARYNCGW
CTTASGSDSS CDIREQCQGP VEWRDSSQHC PNPVIDSFQP ASGPTQGGTN VTISGRNLGK
MIEDVENGIT VAGVRCRPHQ NLYEAASEIV CLTDASTKTR SGPVIVSVND DDHVGESTGV
FSFVTPSISG VSPQIGPKSG GSLLTISGSH LDSGSTSSIA IGNDLPCTIL PTSVQPTLIV
CLTPFLSSES QVNAPIRMRI DNAAFRSRSK FTYLEDPQIL SVYPVRGTLS GGSTVTITGT
NLHAIQAPKM VVYYKNEEYI NNCTVQSENV TLCETPSLVD LLSRVRRAAE PSAEITSLSY
GFIMDNVTSL RNYSAQNGQE FTVYPDPTFV PFEGLVKRFF AEKNDDLLIN GDHLDLVFNE
MNILVTIGGR PCNVTQLSET LLTCTPPPDM VRTGDSHPVV VLVGGKSVSL GELQVEAPVE
QSAFNLYAII GIAAAAAVLL AIILAIVIAY RLQSRESDRV LKRMQNQMDI LESKVAKECK
EAFAELQTEV TDLTSDLGGM SGIPFRDYRS FTMRVLFPTV PENDHPVTRP YEYEHDQYEQ
GLQKFNTLIG NRIFLLNFIR TLENSKDFVA RDKVNVASLL SCALQNRMEY QTEILKTLLS
ELIERAMEGR GTPPKILLRR TESVAEKMLT NWFTFLLFKF LKECAGQPLF LIYRAVKQQI
NKGPVDALTG EARYSLSEDK LIRQQVEYHT MVIGVFLVES WFLIFLRQFS IQQHAVKVLD
CDTISQVKEK ILDSIHKNAP FSCRPSKDDL DLEWITGAQA SLILQDEDRT SKQEGEFRRL
NTLAHYKVPD GAYMALQMKQ IANTQQHNSS NQGMRYGDSY DSYNTSSPSL SRSMSPTAIS
INVDRGKNYH LVKDHDSENM HRGGGDRSSK MVSEIYLTRL LATKGTLQQF VDDLFETIFS
TANRSCSLPL AIKYMFDFLD DQALLHGVTD PETVHTWKSN SLPLRFWVNI VKNPDFVFDM
HKSNIVDSCL SVVAQIFMDS CCMSKHQLSK DSPSSKLLYA KDIPKYKKWV ERYYQDVKLM
PAISDQDMNT MLAEESRTHQ NEFNLNAALY ELYQYVRKYY DEMLISLEED EFAKQYRLVS
RLEQVSMLMT RDSNA
//
