ID R7UM05_CAPTE Unreviewed; 1272 AA.
AC R7UM05;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
DE Flags: Fragment;
GN ORFNames=CAPTEDRAFT_32189 {ECO:0000313|EMBL:ELU04312.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU04312.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU04312.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU04312.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP32189}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR EMBL; AMQN01008212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB302448; ELU04312.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UM05; -.
DR STRING; 283909.R7UM05; -.
DR EnsemblMetazoa; CapteT32189; CapteP32189; CapteG32189.
DR HOGENOM; CLU_001771_0_1_1; -.
DR OMA; PNSWISG; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 7.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 7.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR00003; copper ion binding protein; 6.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 7.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 7.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS01047; HMA_1; 6.
DR PROSITE; PS50846; HMA_2; 6.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796};
KW Wnt signaling pathway {ECO:0000256|PROSITE-ProRule:PRU00069}.
FT TRANSMEM 531..550
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 589..611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 623..647
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 812..833
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1218..1240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1246..1266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 1..63
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 70..136
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 159..225
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 237..303
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 364..430
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 440..506
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 1004..1089
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELU04312.1"
FT NON_TER 1272
FT /evidence="ECO:0000313|EMBL:ELU04312.1"
SQ SEQUENCE 1272 AA; 136915 MW; DEE04FDA21BCD6B7 CRC64;
VFIEGMTCMS CVRNIEGVIS VKPGVKFIKV SLEKKLAYVK FDPSVLTVEA VRQAVDDMGF
EASLDQPQSA QVRISVEGMT CKSCVRNIEE HVGKQDGVQS VEVSLEDKEA LICYEKAKTS
ATALRDLIDD MGFEASLVLQ AFDDLAKERS SSDPEDCGSL AVVSVEGMTC QSCVKSIEGV
VSEKPGVLSI KVSLEDQAAT IRYKAKMTSP EKLCEYIDDM GFEASVRTDK TAHVSNGMCV
ISVKGMVCHS CVNSIQSHIG DMNGVVSIAV SLEEEKAFVQ YNLTLLSSQE IANEIDDMGF
ESKLLDTVLD ADAHSYSVTL DVDGMHCNSC TKTIEGVVGA MAGVNKIEVS LLQANAKVVY
DPSRKCFLRV NGMTCGSCVN NIERGLSRVE GVKTVLVSLM AQKAEVKFDP AYIMPDQIAH
TVTAMGFASS VLESEDAGQG SVEMHIEGMT CASCVHLIES KLVTKPGVLS AVVALATSKG
RFTFDTEVTG PRSIMEFINE LGFTATLTDH DDKSSGMLDH KRTIQMWRNS FLFSLLFGVP
VMLVMMYFMF SMHMADCPEM TTNGTMDMAQ GHECMEVFMV LPGLSLENLL LFLLCTPCQF
LGGRYFFSHA VKALKHRTTN MDVLIALATS ISYSYSVLVC VVAIIMMEKT SPKTFFETPP
MLLVFISLGR WMEHIAKGKT SEALAKLMSL QATDATLVEM DKSGVISRES NIRVELVQRG
DILKVVPGEK IPTDGRVVEG SSTCDESLIT GESMPVPKKP GTDVIGGSLN QHGTLLVQAT
HVGSESALAQ IVKLVEEAQT SKAPIQKLAD TIAGYFVPAV VSLSLLTLIA WVIVGYVDLD
LICCSLGCTF SRLFFTQERG QNKHEAIFEH AFKFGITVLC IACPCALGLA TPTAVMVGTG
VGATNGILIK GGEPLETIHK IRSIVFDKTG TVTHGVPRVA RICMFVEPAV CSLQWLIAIA
GTAENSSEHP LATAIVNYAK KALQTEALGK TADFTAVPGC GLKCNVSQVE YLLEDNHDPK
SGSVRSLQAM TISVGSHRVL MGNREWMQRN GMLVTPEIDS KMEEHEVQGH TAILCAIDGR
IIAMLAVADT VKSEAHLAVY TLKKMGLNVM LLTGDNRRTA RAIARQVGIE TVFAEVLPSH
KVAKVKQLQA LGSAVAMVGD GVNDSPALAQ ADTGIAIGTG TDVAVEAADV VLIRNDLLDV
VGAMSLSKKT VNRIRINFVA ATIYNIIGIP IAAGCFMPLG LELMPWMASV AMAASSVSVV
CSSLLLKMWT KP
//
