ID R7URK3_CAPTE Unreviewed; 1670 AA.
AC R7URK3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
GN ORFNames=CAPTEDRAFT_228900 {ECO:0000313|EMBL:ELU08773.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU08773.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU08773.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU08773.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP228900}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AMQN01006627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB298780; ELU08773.1; -; Genomic_DNA.
DR STRING; 283909.R7URK3; -.
DR EnsemblMetazoa; CapteT228900; CapteP228900; CapteG228900.
DR HOGENOM; CLU_241835_0_0_1; -.
DR OMA; AWILMWI; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF145; POLYCYSTIC KIDNEY DISEASE PROTEIN 1-LIKE 1; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1047
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1067..1092
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..322
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 555..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1386..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1641..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1386..1421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1441
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1452..1466
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1641..1655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 806..819
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 1670 AA; 186691 MW; 7FC6BFFED9E1485F CRC64;
MACCLRELPS VLNDLINMQR SYSRGLPNTL GPVILNLIER PHQSTLHMSQ RPFSPHPGSR
VFYLGVVDAS FNAGRPREGE VRRREYRLQL WQGQCLYWDQ ELDDWSSQGC KIISEHSSYY
KAHCSCNHLT SFGAHFALSP NTLDFKNIDD FFDLHTNPVT FSFILAILIT YGILMVIAVQ
KDNQDAAQPP IVELMDNSPS DKQKYLVSLE TGFRKGAATT AKVSLVLHGE EGMSETRELV
GRETKPIIFQ RHSRQSFILT LPENLGRLFK CQIWHNNAGE QPSWYLSRVI VQDLNTGYFY
YFMCERWFAA DIGDGKVERE IMASEGGLGF SKVLWAKGTQ YFADYHLWFS TFSRPPHSRF
TRAQRLTCCL SLLMSYMALN CVWYKGTEKD YRGEFGMIDL SWRAVVVGAI ISLIALPANL
IIVMLFRRSK VNFLERPHSA FNKKYKTTKR NDSVSSIGST DQSLGPPVMS PSLFDQTISN
WQSLQDWAQK TWTRRNPDEE DSIDKKAVDT STLETNMSDR IESVMKEETK DVTPPLASVE
LRKKANDAEI ELRPIPPRHI KSVLHPGLPQ GPTTPGSSGQ GPREALRGRT LPWMTAAKVL
LLSVIVAMRN RNNIHIFSHH DDGYLDQKVL KMLKSKPKSK EDDEDESVNL EEGVAARQRS
RYLRFARPPQ ETELLKSRND ILKQKGASAF IKLVLFIPPS ASTFCILIIS SETLLFTVQF
VLLVLIAFGK NPTHAFGIHR HVTATLAQDG EHPLAKVHSI SQMWKWMQGH FTDTMYDDPT
RPGFLSNSYL IGQVQLRQHR FTNQLCDVQV EKLLVSGNCR GDMEMDAFGM NQSYWYHSAE
LTGAGRVQGQ HDDYGGDGYL VKLPNRRLPA EAQLKKLEED GWVNSMTSAV IAEFTTFHVP
SNIFNTVRIL FEIPAFGGMT PSLKISSAYL YKYVSVMDNL LLACELLLIV CTMLKVRHEV
MEMLRLKAEY FHNVWNALET SQCLLSLAFV GCFMFRFLLV GAKVQDLRST YKEQFMDVSD
VHEWDEVLRT IIGFILFLVT LQLVKALRHQ PPFSVFAKVY HRAAMDILVF ALMFFIWLAS
YTCLTMALYS ALSMQFKSVD NTILSLLALL TGSYDFDNLA FGNFWGVFVW RLVIVSFMMF
VIGSLTAYML AILNYHYKRH HSEKKVTFNL TESVRFCRNR LSNVFRLRAA SSEDPPSSAS
ASASGKTEPE TLLPTEFTMA EIEYQVDEML FKMNALAGTS NLPEKPPIYY TDSDTCIYGG
VGGSGEGDSS TTASSEVQGF NPLQELRGNH KIEYIFSEPH LSKLLQLDSI GADVLNVPEA
DVEKQLRNQL EMEIFRQLQL QRQEGRYPSS SGSGVGEGEG EVGGGEGGVV GVGERGSEAL
DVYASSLSSS GCNHSPTPAS VGGAKSHTID ESDSVTCNDP LPILNSIPFH PEPPAPPQVK
PSAPHSIGGR KLQQRKDKKK KKKKVHSASS SEALVVEEMP DSVIGIRSDS ADSSSCCSGS
HKAANRGNSL HPGMPVPPLH PCSNTTPAES KRAAKSKKSS QAQLHKKTPV PQYNEGGLNQ
ILNSWDDLDF SCSTSPSSSP SSSSSESEEQ TPPAQSKAQQ HSTRGTLRKT RSRGGGKGQG
HAVAACDLLS LTEDEFAFDN HGYASEGDRV RAGQKKYRKP PPPATKQCWS
//
