ID R7UWS1_CAPTE Unreviewed; 468 AA.
AC R7UWS1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=CAPTEDRAFT_181870 {ECO:0000313|EMBL:ELU08382.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU08382.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU08382.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU08382.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP181870}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AMQN01001088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB299137; ELU08382.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UWS1; -.
DR STRING; 283909.R7UWS1; -.
DR EnsemblMetazoa; CapteT181870; CapteP181870; CapteG181870.
DR HOGENOM; CLU_584288_0_0_1; -.
DR OMA; PREGVNT; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR PANTHER; PTHR24044:SF417; EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF12661; hEGF; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|RuleBase:RU280815};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815}.
FT DOMAIN 159..204
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 209..245
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 247..283
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 318..351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 393..429
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 161..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 174..186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 235..244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 273..282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 341..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 419..428
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 468 AA; 50916 MW; CE75A8D7D4ADECF9 CRC64;
MGSVVEGSAV FKLLLVKYDN RNEKDWGGSC CDQWCAGGCD HKFTFCFDEY NGNDNFRSCE
HGRWTSREIN NANVNTFRNS IGGVPNPITK YFTSWPGGLK FKTEVYDDDD FNSSDLVDRL
FKLINLTPAK GAATSTWHTT DIVGTRSRKK TTLSIKYMAY CDKNYFGAKC DVHCKAMDSA
EGHFRCDPDT GAKVCLSGWE DPKKSCTILK DNCAAVQCLN GGTCIDLYNS YICTCPSGFE
GDHCELNLDD CASQPCQNGA TCVDGEDSYI CQCSPGYVGI NCESHVCATP SDVCLNGGTC
YGTGQCFCPP GFVGSTCDIH RCNVTVCLNG GTCNDDGTCT CPPAYLGALC GVNMNAWLEH
ACGTLVHCDN GGTCHIGKCY CSEDYTGKYC SSRIDDCVGN PCLNEGVCED GVSSYTCRCQ
ADYNGTHCEE ELGPPVWEEQ ILKNVTDEVF DVPTMKEVTI MCVCWVGG
//
