ID R7UZK5_CAPTE Unreviewed; 1211 AA.
AC R7UZK5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_206062 {ECO:0000313|EMBL:ELU08876.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU08876.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU08876.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU08876.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP206062}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; AMQN01006591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01006592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB298689; ELU08876.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UZK5; -.
DR STRING; 283909.R7UZK5; -.
DR EnsemblMetazoa; CapteT206062; CapteP206062; CapteG206062.
DR HOGENOM; CLU_269738_0_0_1; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd00198; vWFA; 1.
DR CDD; cd01450; vWFA_subfamily_ECM; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 5.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00092; VWA; 5.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00327; VWA; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF53300; vWA-like; 5.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50234; VWFA; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1211
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008788529"
FT DOMAIN 31..225
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 249..441
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 478..670
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 703..1010
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1026..1158
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1021..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1182..1197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1211 AA; 130850 MW; 29C7CE420C414369 CRC64;
MTTPTLRAFS LLILVVVNSK GQNDCDSSVL DLVFIVDGSG SICEQEMRAT TGLQGCKNWN
TVINFINSFI ESIGVSENGN HIGIVLFATE ATNAVKLKQY TSTSSLNNFI KSNMIYPDGS
TNTAEGLDMV LKNYLNTNDD RPEARNVVIM ISDGIPTEPT SNIVARQLAL EAAKKVQSES
TVFTVGITEA IDEEFLAAVS SGGQKGVDWF ETATFEGLTE IRESVVKNTC ATTTTPKTTI
SECTDSVIDL VFVVDGSGSI CDNDPSRKND GSGCDNWKQI VNFITEFVTV MEPSETGTHV
GLVSFSTESL LLAGLSRYYS ANSLNEYIEG NLMYPGGDTN TTGGLEMTKD KVIGQAGDRE
PVRNVVVVIT DGIPTFPKPN PRQRALDMAN LLKGQADVFA VGVTNQTDDA FLSNISSGGV
QNVNWFHSAS FEGLQEIRDQ AYALCDAMNG MAPQTVVKLL KAKIIIATWC VETDSVIDLV
FVVDGSGSIC DNDPSRKNDG SGCDNWKQIV NFITEFVTVM EPSETGTHVG LVSFSTESLL
LAGLSRYYSA NSLNEYIEGN LMYPGGDTNT TGGLEMTKDK VIGQAGDREP VRNVVVVITD
GIPTFPKPNP RQRALDMANL LKGQADVFAV GVTNQTDDAF LSNISSGGVQ NVNWFHSANF
EGLQEIRDQV VQQACITTTR QTVPSTTTAS LTTRCIETET RVDLVFIVDG SGSICNNNPR
LGDGKGCNNW QLMVDFIIQF VESLDPSVSG SHIGLLSFAT DPIYLAGLNR YLDTAGLVLY
IKDHLDYPGG DTNTTGALEM AKDRMFGLNG DREDVPNVAV LLTDGIPTVP PPNAKYASVQ
PVEEGSHIGL LSFANSPIFL SGLDGYIEQC QSEANIFTIF FPCLQRFYNT EDMIEYIRQQ
LMYPGGDTNT TAGLEMAMTK EFGKSGDRAD ASNVVVVITD GIPTLPEPNA REKALAMAGE
LKKVAQVFAI GITNQTDDKF LSALSSGGVQ NENWFNTPTF EGLQGIRDQV IQLTCAAQNS
DTTTRPSFTV SSTENPSPTP TTRGTTSSGD IITGNIRLQP SVLFLHRSFP RRLICTIPNT
ANLPITWNDV EWYSPSGQRI PSYGENYMTS LTYSMGRGGT SYWTGSLWIT PSSYALNGQY
TCRVNYNGVV SSRSSFVAIK ACMTGQFTCA KGNTCIPCSY VCDGLNDCGD WSDEFTCSGG
KSPSSNDLNC V
//
