ID R7V3L4_CAPTE Unreviewed; 709 AA.
AC R7V3L4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN ORFNames=CAPTEDRAFT_219731 {ECO:0000313|EMBL:ELU10395.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU10395.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU10395.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU10395.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP219731}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC {ECO:0000256|ARBA:ARBA00037788}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; AMQN01006077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01006078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01006079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB297541; ELU10395.1; -; Genomic_DNA.
DR AlphaFoldDB; R7V3L4; -.
DR STRING; 283909.R7V3L4; -.
DR EnsemblMetazoa; CapteT219731; CapteP219731; CapteG219731.
DR HOGENOM; CLU_389463_0_0_1; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd00174; SH3; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 403..463
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 564..628
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 709 AA; 78123 MW; 83694C732836ED92 CRC64;
MASVGSADVE AKAALYRTHL FMFSDVLLAS QLHVDAAGGK GLACCVDIQK EDAVKQAVEE
AVATFGGIDT LINNASAIHL TGTMETPMKR YDLMHSINTR GTFLCSKYCL PHLKKSPNPH
ILNISPPLSM KPKWFKDNVA YTMAKYGMSM CALGMAEEFR ADGVAVNTLW PRTAIYTAVM
AMLGGGEAVK PQCRTPEIMS DAAYAILTRD SRSFTGNFCV DDDILKEEGM TDFTKYNYVE
NPTLLPDFFL EEAGDREQFL GQLTEQGGKP KDFSQAGSDL EKTFKAVEGL LSADLVKTVN
GVFAFDLGDA GSFYLDLKNG NGAAGKGPAP QGEANVNMIL NAENFVKMFA GKLNPTTAFM
SGKLKIKGKT SRSVPWSLGV GRLTGSDSLD TLVHLEAMKD NESPKPTMVI VQDFKPCVED
ELAVSRGQTV RLIFQENDWM FVEKCEGSGQ GFVPYTYCLP IRDEQLSTLN EESTSLRIPL
VDLSGNFRDS CSVGQSTESS EDQCGGPWST GQILTNGAKS RPSNVHRPID YTRTSELTPD
AINDSAANAD VQPHATWCNS FEKRNLGKYI VLFNYWSEDE NDACVQRGDF VTLLNKDDPD
WFWISRKTKA GNPLEGFVPS NYLSPAVVRE SYEDSSMLPY DGTRRRKSPA LMVCTRDYRT
ELGEDFNLRE GDVVQVLDST SSEDEFVLVF ALDSQQTVHI RRSCIRPLD
//
