ID R7VGC6_CAPTE Unreviewed; 4224 AA.
AC R7VGC6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=CAPTEDRAFT_174329 {ECO:0000313|EMBL:ELU15361.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU15361.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU15361.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU15361.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP174329}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AMQN01004546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01004547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB293809; ELU15361.1; -; Genomic_DNA.
DR STRING; 283909.R7VGC6; -.
DR EnsemblMetazoa; CapteT174329; CapteP174329; CapteG174329.
DR HOGENOM; CLU_000038_0_0_1; -.
DR OMA; HNVAKMV; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760}.
FT DOMAIN 1517..1656
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2165..2313
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 917..944
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2994..3056
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4224 AA; 481738 MW; 39C008D5D39C8C6F CRC64;
MSLRPLRSSH SRPFSANRTQ SNLEPKTTQD GRKYPEIQQK GYYSDILDPT ANEKLENVLS
GPQTDQDTLW NVSKEKYTPK VTSFNTPQDL SDEALDHGPS TEITAVSDFP IQSYQPKVQK
PFFAAPGDCP RKIEIERRKR HYAKQNLNAL LSRYDIDTSQ LMPKHHPEGI KNIKLNADPN
DPAPFPPYLP IHLFDDDEFE IRNPEEWLEM GMENGVRKPV PGKALLPTKD DVHHLDPKDP
SIEYKWFDVG VLDYVDEQRL FLVQKVNSHN RIVDDKGKPV VNGGVGSDGK RKVLPNQFLI
PRIRLSFAAE DPDIFAQRVQ HAFNYRKSTE ALLRYNLYID CMPMEGVGEL DQASLKRMTE
WAKGAPSLAK DKGLDDYIQV LEKEVNIDFC RSMNQIIFDK TIDDDPLTFA FVTAPPKNEE
AVPERGCCMD VPEFPFDEQY DSFAFNSLLT REEAISAIGK VGTECNKVAG MSLFHIPTAK
HMRLEEFEQT QAQATSQVSL FLKDSWITTL RAAIRTSLRD VGKGWFNLHE TNWEVYQISK
LKKFMEMVKF NMQDSLRYLV QDSLVNFTQM ILDACHATLQ CKDDMVWGKN IILSQFKPKR
NALFLVDLVM DNQGVHYSSN LNSFESTIVS LFDRGIQSTQ NVPQLEKHIM EDIFWSGTPL
LESVGEHEPP VEELRATICD ALTHSVIPMK AYAKEYEQFL ELMNMDINEY IKVYEAENHS
AAEVKQEVEM HLKEKEIIEG LLPSNIIIGP FWISTENVRQ ALSKKRKALG NAVLELLARK
LRTQADEACE VFKAISRRLY EKANCIEELS EMKEWMKSIP ETLREHQETI DKAMSDYSLI
EDFYYNLSTD DFNAKWNAIG WPHKIELQME QTETQLDEDE ERFHKLQMSD QGNFNDRLDS
LAMLVPGMAA HTDISKAHEV ANQVRRIQKD LKDAQTDALK YNNRERLFGM PITNYDKLSK
LIKDFEPFRN LWVTTSDWLR WHDSWMNDPL SSIDAETVDK NVSDAFKIMH KSAKIFAEIP
GVSEVANEIR RNIEDFRPKI PLIQGLRNPG MRNRHWEQLS DALGFPIRPK ANLTFSKCLE
MKLEDHIQVI SKVAEVAGKE YSIEQALDKM ENEWAPVNFE IIPYKETGTF ILKASEEISQ
LLDDHIVMTQ SMSFSPFKKP FEERISTWES KLRTTQDVLD EWLQCQRQWL YLEPIFSSDD
INRQLPTESK RYQTMERLWR KIMKNAKENA QVISLCPDNR LLDNLRECNK LLEQVQKGLS
EYLETKRNAF PRFYFLSDDE LLEILSQTKD PTAVQPHLRK CFENIAKITF QEDLKITEMI
SSDGESVPFQ ESLYPKGNVE DWLLEVERVM RESLRTILER ALLDYPKCPR TEWVLKWPGQ
LVIAGCQTFW TSEVSEVLEQ GNLKTIYPKL LDQLDGLRGL VRGQLTPIHR SILSALIVIE
VHARDVVNNM IEEKVQNIND FEWISQLRYY WHDDWLYIRA VNAEFPYGFE YLGNNGRLVI
TPLTDRCYLT LTGALHLKFG GAPAGPAGTG KTETTKDLAK AMAVQCVVFN CSDQLDFMAM
GKFFKGLASA GAWACFDEFN RIDIEVLSVV AQQITTIQKA LEQKLDRFMF EGVELSLKPS
CSVFITMNPG YAGRTELPDN LKALFRPVSM MVPDYALIAE ISLFSFGFSD ARVLAKKIVT
TFKLSSEQLS SQDHYDFGMR AVKSVISAAG NLKRQNPDSD EELVALRAIR DVNVPKFLMD
DLKLFNGIVS DLFPNIKEEK IDYGELETSL RKTCTKMKLK DVDSFIHKCI QLYETTVVRH
GLMLVGPTGS GKTKCYEVLQ GAQTAVKGAV QPSGDLFEAT HTYVLNPKSI TMGQLYGEFD
MLTHEWTDGI LSTLIRIGSA STDSDKRWYM FDGPVDAVWI ENMNTVLDDN KKLCLSSGEI
IKLTDHMTMM FEVQDLAVAS PATVSRCGMV YLEPGILGLA PFVECWLKYL PDVVYEFKDT
FQRLFDIFLE PGINFLRANM KEIVPTMDSN LTFSMFKFME CFFKPFLPKE GEKPIPDERA
SRMRELVEPW FIFSFVWTVG ATCDNDGRKR FDKWVRETMA EAKLELLFPD AGQVYDYKLD
DAGISLPALE EDEEEELKSR SVRWIGWMSE LAPFVIAPET KYSDIMVPTL DTVRGAHLIE
MLLSNNKTVL VVGPTGTGKT MAIADKLTTK MPKEYIPDFI TFSAKTSANQ TQDLIDGKLD
KRRKGVFGPP LGKYFVFFVD DLNMPALEVY GAQPPIELIR QWMDFKGWYD RKAIGEFRRL
VDVNFICAMG PPGGGRNPVT MRLMRHFNYL AFTELEDISK KGIFSAILDW WLEKAPSLRQ
HCGTLVEACI DVYNVITTQL LPTPAKSHYT FNLRDLSKIF QGMLMGDSSK LTGVPDLLRL
WYHESQRVFA DRLVNDEDRD WFSNQLKEQM MTKFDTDISD VIKQEPTLYG DFLTSNVDNR
PYEEMEDHEK MVKVVEEYLE DYNQINTAQM RLVMFMDAIK HLCRICRIIR QPLGNALLLG
MGGSGRQSLT RLAAHMAEYD LFQIELSKNY GMAEWREDLK KAMLKAGLEN NAMVFLFSDT
QIKSESFLED INNILNSGDV PNLYAFDDLD QIYTTMKPIV QDLGLQPTKT NLFSLFTKRV
RSNLHTVITM SPLGEIFRAR LRQFPALVNC CTIDWFSEWP ADALKSVAVR FLGDLPDLDA
TDDVMDGLVS MCQTVHSSVM TLSGRLASEL NRFNYVTPTS YLELLGIFSK LIGTKKMELN
TARNRTKTGL DKLLSTADEV AKLQEELETM RPLLEEAVQD SMVTMVKIAE DSKVAEETKV
VVSKEEAGAV LKAKETQAIA DDAQRDLNEA LPALDAALQS LKSLNKNDVV EVRALQRPPD
GVRMVIEAVS IMKSVKPKKI PGDKPGEKKD DYWEPGKSLL QDPGKFLESL FKYDKDNIPD
TAISKIQPYI DNEAFQPAAI AKVSKACTSI CQWVRAMHKY HFVAKGVAPK REALALAQAD
LAETQRVLDA AKKRLQEVEE GIATLQAKYE DCVRKKEELE QKTEECEQRL VRADKLRKVT
KMPTTCNKNR LITDRFIFQL IGGLSDEKGR WQESVKTLQA VVDNIVGDIL VSAGSIAYLG
IFPGEYRSDV TASWMTSLKD QKVPHNDGAS LIDTLSDPVK VRSWQICGLP KDNLSVENGV
IVQYSRRWPL FVDPQGQANK WVKNLEKDNG IDTIKLSDRD FLRSLENAVR FGKPCLLENV
GEELDPALEP ILLRQTFKQS GSLVIKLGDA IIPYHEDFKF YITTKLPNPH YTPEISTRVT
LVNFTLSPSG LEDQLLGIVV AEERPDLEEA KNQLIVSNAK MKQELKEIED KILQRLSASE
GSPVDDIDLI NVLEASKIKS EEIKAKVIIA EQTEKDIDET RSLYIPVAVN TQILFFCVAD
LASIDPMYQY SLEWFIRIFL NGISNAERAD NVPDRTVKIN EFFTFSLYCN VCRSLFEKHK
LLFAFLLSVR ILQHEGKINM DEWRYLLSGG TAKPKDLPNP APSWLSIRSW GDVLTLAALP
KFADFAEDFA NHLDVYRTIF DSVEPHRDAL PGKWNDELDN FQKLLVMRCL RPDMMTNAMQ
DFVANHLGQR FIEPQTSDLG LVFKDSSPST PLIFVLSTGT DPAVDLYKFA EEMRFSKKLS
AISLGQGQGP RAEAMMRSAM ERGKWIFFQN CHLAPSWMPS LERLIEQIDP DKVHRDFRLW
LTSMPSPKFP VFILQNGSKM TVEPPKGIKA NMMRSYMSFS DDFLTSTGHK TPDFKHLLQS
LCLFHGVVLE RRKFGPLGFN IPYEFTNGDL RICISQLKMF LEEYDEIPFK VLKYTAGHIN
YGGRVTDDWD RRCLMNVLGD FYSEPVLETN FKYSTSGIHY QLDPDNDLAG YLAYIKSLPI
NDTPEIFGLH ENANITFAQN ETYALLSGLL KLQPKSSSGG GQTREEVMEE TAKTILGQVP
PPVPIGPVMT KYPVMYEQSM NTVLLQEIIR YNRLLSTIKQ SLNDLLKALK GLVVMSQQLE
DMANSLFINQ VPGMWAGKAY PSLKPLAAWV TDLVQRMKFL QSWIDDGIPP VFWISGFFFP
QAFLTGTLQN YARKKVISID TISFGFEVLK ADAELTKGPN DGCYIRGLFA EGMRWCDQTH
QLTESRPKEL FTDMPAIWLQ PEADRSVAKT GFYSCPVYKT LTRAGTLSTT GHSTNFVFTV
ELPTDKGQKH WIKRGVAMLC ALDY
//
