ID R7VS61_COLLI Unreviewed; 443 AA.
AC R7VS61;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Neuropeptide Y receptor type 5 {ECO:0000256|ARBA:ARBA00019481};
DE AltName: Full=NPY-Y5 receptor {ECO:0000256|ARBA:ARBA00032994};
GN Name=NPY5R {ECO:0000313|EMBL:PKK21704.1};
GN ORFNames=A306_00013830 {ECO:0000313|EMBL:PKK21704.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK21704.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK21704.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21704.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of
CC this receptor is mediated by G proteins that inhibit adenylate cyclase
CC activity. Seems to be associated with food intake. Could be involved in
CC feeding disorders. {ECO:0000256|ARBA:ARBA00024704}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK21704.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCR02000075; PKK21704.1; -; Genomic_DNA.
DR RefSeq; XP_005513837.1; XM_005513780.1.
DR AlphaFoldDB; R7VS61; -.
DR STRING; 8932.R7VS61; -.
DR GeneID; 102097007; -.
DR KEGG; clv:102097007; -.
DR CTD; 4889; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; R7VS61; -.
DR OrthoDB; 5361264at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR CDD; cd15398; 7tmA_NPY5R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000393; NPY5_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR PANTHER; PTHR24235:SF10; NEUROPEPTIDE Y RECEPTOR TYPE 5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01016; NRPEPTIDEY5R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PKK21704.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 55..422
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 443 AA; 50277 MW; 403A73C7D07BB2BB CRC64;
MDLGFKDHNN RTPTKNTSAT TKNFSVWEDY KSSVDDIQYF LIGLYTLISL AGFMGNLLIL
MALLKRKQKS IINILIGNLA FSDILVVLFC SPFTLTSVLL DQWMFGTIMC HVMPFLQCAS
VLVSTLMLIS IAAVRYRMIK YPLSSNLTAK QGYFLIVTIW AVGFAICSPL PVFHKIVDLS
KTLNVELLEN RLLCIESWPS DSYRIAFTIA LLFIQYILPM VCLTASHTSV CRSVGARLST
KENKFEEKEM INLTLHASKS TGMQVQPSSH SRWSCTFGRK HHRRYSKKTS SVMPAISRHH
QDTHPRDLPE SSGTEKSQLS SSSKFIPGIP ICFEMKPEEN TEIQDMITVS RSIIRIKTRS
RRVFCRLTVL ILVFGFSWMP LHLFHVVTDF NATLISNRHF KLVYCICHLL GMMSCCLNPI
LYGFLNNSIK ADLLSLIPCC QIP
//
