ID R7VTF0_COLLI Unreviewed; 442 AA.
AC R7VTF0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 (Putative), transcript variant X1 {ECO:0000313|EMBL:PKK21373.1};
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 6 (Putative), transcript variant X2 {ECO:0000313|EMBL:PKK21374.1};
GN Name=ENTPD6 {ECO:0000313|EMBL:PKK21373.1};
GN ORFNames=A306_00011229 {ECO:0000313|EMBL:PKK21373.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK21373.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK21373.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21373.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
RN [2] {ECO:0000313|EMBL:PKK21373.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:PKK21373.1};
RA Holt C., Campbell M., Edelman N., Keays D., Kapusta A., Domyan E., Suh A.,
RA Carleton J., Warren W., Yandell M., Gilbert M.T., Shapiro M.D.;
RT "Improved genome assembly and annotation for the rock pigeon (Columba
RT livia).";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK21373.1}.
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DR EMBL; AKCR02000085; PKK21373.1; -; Genomic_DNA.
DR EMBL; AKCR02000085; PKK21374.1; -; Genomic_DNA.
DR RefSeq; XP_005512093.1; XM_005512036.1.
DR RefSeq; XP_005512094.1; XM_005512037.1.
DR AlphaFoldDB; R7VTF0; -.
DR STRING; 8932.R7VTF0; -.
DR eggNOG; KOG1385; Eukaryota.
DR InParanoid; R7VTF0; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF99; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 6; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833, ECO:0000313|EMBL:PKK21373.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT ACT_SITE 185
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 215..219
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 442 AA; 49049 MW; 1BB72C1B3C6B8CFE CRC64;
MEAMKISKRF FAFGILACIA LYVAYIKCCL DSKPVMGATE GAAESRGDKP SYQALTADLS
VFYGIMFDAG STGTRIHIFK FTQQPKETPK LTHETFKALK PGLSAYADDV EKSGQGIKEL
LEVAKKDVPM ELWKFTPLVL KATAGLRLLP GEKAQKLLDK VKEIFQASPF FVRDNCVSIM
KGTDEGISAW ITINFLTGSL DDPQKRSVGM LDLGGGSTQI TFLPRTEATL QTSPAGHTTS
FQMFNNTYKL YSYSYLGLGL MSARLAILGG VEGETLGEGE ELISPCLPPG FESEWQHAEI
MYKIKGQKAG EPLYESCSNE VAKVLYKKVH KAEEVKDLDF YTFSYYYDRA ADVGLIDKEK
GGSVTVGDFE IAAKYVCKTM EISPRSSPFL CMDLTYITFL LQELGFPKSQ VFKLARKIDN
VETSWALGAT FHYIDSLNRL QY
//
