ID R7VX22_COLLI Unreviewed; 425 AA.
AC R7VX22;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Bone morphogenetic protein 10 {ECO:0000313|EMBL:EMC87216.1};
GN Name=BMP10 {ECO:0000313|EMBL:PKK18265.1};
GN ORFNames=A306_00013734 {ECO:0000313|EMBL:PKK18265.1}, A306_04085
GN {ECO:0000313|EMBL:EMC87216.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:EMC87216.1};
RN [1] {ECO:0000313|EMBL:EMC87216.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:EMC87216.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
RN [2] {ECO:0000313|EMBL:PKK18265.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:PKK18265.1};
RA Holt C., Campbell M., Edelman N., Keays D., Kapusta A., Domyan E., Suh A.,
RA Carleton J., Warren W., Yandell M., Gilbert M.T., Shapiro M.D.;
RT "Improved genome assembly and annotation for the rock pigeon (Columba
RT livia).";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KB375463; EMC87216.1; -; Genomic_DNA.
DR EMBL; AKCR02000216; PKK18265.1; -; Genomic_DNA.
DR RefSeq; XP_005505296.1; XM_005505239.1.
DR AlphaFoldDB; R7VX22; -.
DR STRING; 8932.R7VX22; -.
DR GeneID; 102086297; -.
DR KEGG; clv:102086297; -.
DR CTD; 27302; -.
DR eggNOG; KOG3900; Eukaryota.
DR InParanoid; R7VX22; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19401; TGF_beta_BMP10; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF39; BONE MORPHOGENETIC PROTEIN 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..425
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004458630"
FT DOMAIN 314..425
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 425 AA; 48288 MW; 9E8BFDA63B386ADD CRC64;
MDSVVLQLGA ALCLLGHLAT CSPILSLEHS SLEEDVPLFD EILSEQDGVD FNTLLQNMKN
EFLKTLNLSD IPLHETAKVD PPEYMLELYN RFATDRTSMP SANIIRSFKN EDLASHPVGV
TGIRKYPLLF NVSIPHHEEI TMAELRLYTL VERDQRLYDG LDRKVTIFEV LENDHIGVGE
ERKTVALASR QIYGTSSEWE SFEVTEAIRR WRRAGLTTHR LEVHIESREG EEQNGEGKLD
IDINSEAKHV PLLIVFSDDQ SNDKKEEKQE LNEMIDHEQL LDLENLEVGN FHGQPGEEAL
LQMRSNIIYD STARIRRNAK GNYCKKTPLY IDFKEIGWDS WIIAPAGYEA YECHGVCAYP
LTEHVTPTKH AIVQTLVHLK NPQKASKACC VPTKLDPISI LYLDAGVVTY KFKYEGMVVS
ECGCR
//
