ID R7XVS6_9ACTN Unreviewed; 720 AA.
AC R7XVS6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=MMPL domain-containing protein {ECO:0000313|EMBL:EON23406.1};
GN ORFNames=CF8_2613 {ECO:0000313|EMBL:EON23406.1};
OS Nocardioides sp. CF8.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=110319 {ECO:0000313|EMBL:EON23406.1, ECO:0000313|Proteomes:UP000015971};
RN [1] {ECO:0000313|EMBL:EON23406.1, ECO:0000313|Proteomes:UP000015971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF8 {ECO:0000313|EMBL:EON23406.1,
RC ECO:0000313|Proteomes:UP000015971};
RX PubMed=23833136;
RA Kimbrel J.A., Chang J., Arp D.J., Sayavedra-Soto L.A.;
RT "The Draft Genome Sequence of Nocardioides sp. Strain CF8 Reveals the Scope
RT of Its Metabolic Capabilities.";
RL Genome Announc. 1:e00439-e00439(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON23406.1}.
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DR EMBL; ASEP01000083; EON23406.1; -; Genomic_DNA.
DR RefSeq; WP_010833480.1; NZ_CM001852.1.
DR AlphaFoldDB; R7XVS6; -.
DR STRING; 110319.CF8_2613; -.
DR PATRIC; fig|110319.3.peg.3283; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_1_1_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000015971; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015971};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 226..351
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 553..696
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 720 AA; 75061 MW; 0D2A0C480E3E1601 CRC64;
MSTTTAPSKG APDFTPGFRP GPLGRLGLWV SGHAKLVTGV WLLLIVGLGA FAPQVEHNLS
GAGWQADGSE SVAARELAQE SFGGNASSAI QVVVHSTDGP VTEGPGAEVL AQVTRMLEAE
PRIAEVIAPM PGATISQDGS TAIILAGAGA DTNEMVRVAT DLKGDLQDLS VEGIQVNPTG
SSLLWSDFNE ANLEAMLKSE MVSWPVTMAI LVLAFGALVA AGLPLILTLA GLVASAGSLV
LINELVPVSI WAMNFAMMFA LALGIDYALF LVVRYRASRM GSGNSARQAV AETMDTAGKA
VLLSGATVLI SLSAVMLVPS PSFRSMAGGI MLSVVFVLAA TLTLLPLVLF KLDHKINKLS
LPWVKTGEHR SPKFAAWGER LWKRPLVWGL GALIVLLALA APIIGLKTAM PSIKVLPEDA
SARVGYDLVQ ESFGEGAPGT LQIVMKASDA DAAKTVLASD PGIAGAMPSM PAADDSGLVL
IQAVPTVDPS DPALNDTVDR LRADLPSSAL VGGAAVENLD LKAQLDESTP LVIGVVLVLG
FLLLLVALQA PLISLLGTLA SLLSTAAAFG VARLVFQEGI GADFFGFESQ GFLDAWAPVF
FFAMIFAIAM DYTVFLLASA KEHYEHSGDP KDAMVGSLAH SGRVIFAAGA VMVAVFFTFA
LSGPLPPKEM GIVLGVAVLL DAFLVRLVLL PVMLRLTGKA AWWSPAWLRR VLPTITFSHG
//
