ID   R7YRD9_CONA1            Unreviewed;      4895 AA.
AC   R7YRD9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN   ORFNames=W97_03605 {ECO:0000313|EMBL:EON64374.1};
OS   Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetes incertae sedis; Coniosporium.
OX   NCBI_TaxID=1168221 {ECO:0000313|EMBL:EON64374.1, ECO:0000313|Proteomes:UP000016924};
RN   [1] {ECO:0000313|Proteomes:UP000016924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 100218 {ECO:0000313|Proteomes:UP000016924};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Gorbushina A., Noack S., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Coniosporium apollinis CBS 100218.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC       of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC       {ECO:0000256|ARBA:ARBA00004642}.
CC   -!- SIMILARITY: Belongs to the midasin family.
CC       {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR   EMBL; JH767568; EON64374.1; -; Genomic_DNA.
DR   RefSeq; XP_007779691.1; XM_007781501.1.
DR   STRING; 1168221.R7YRD9; -.
DR   GeneID; 19900916; -.
DR   eggNOG; KOG1808; Eukaryota.
DR   HOGENOM; CLU_000050_0_2_1; -.
DR   OMA; ILEQWHR; -.
DR   OrthoDB; 1221059at2759; -.
DR   Proteomes; UP000016924; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR040848; AAA_lid_7.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR048617; MDN1_AAA_lid_4.
DR   InterPro; IPR012099; Midasin.
DR   InterPro; IPR041190; Midasin_AAA_lid_5.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR   PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR   Pfam; PF07728; AAA_5; 9.
DR   Pfam; PF17865; AAA_lid_5; 1.
DR   Pfam; PF17867; AAA_lid_7; 3.
DR   Pfam; PF21108; MDN1_4th; 1.
DR   PIRSF; PIRSF010340; Midasin; 1.
DR   SMART; SM00382; AAA; 6.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR010340};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016924}.
FT   DOMAIN          4673..4883
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          744..767
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4046..4429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4465..4553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4050..4076
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4090..4104
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4105..4154
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4155..4202
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4216..4263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4264..4279
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4283..4297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4332..4346
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4353..4376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4404..4418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4895 AA;  545414 MW;  50A4F78C1ED49FBB CRC64;
     MDCSQCTSAL LSQLDRLPPS LIEVLRTGSN QEYLDSIASI ALTPHLTDKI FVSCEPLFAE
     ICARWTSGPS NSPLGRIAAL GRILPFAPYL AEYAENYLAA LSASGKKLDA LISARSIAPA
     KDGVSEADLR ELLHGLFRLL VLDRSSFGRF VKISTLQNLL QHGDRATRYL AIRVLCLHLQ
     AADAAMQAMI AKHLGAGPIL GLWEGRNIDY RFFSLWEEKR SEDVSKRLLE ARLLRENSVE
     EPKHCRVVTQ EDLMDMVVEV YGLLLPRLGA HILENSHHFS LVPTATIVRN VKSVAEGLLS
     PQPLLLTGLA GSGKTLVVTH LARLLNKLST MITLHLNEQS DAKLLIGMYT AGATPGTFAW
     KPGVLTTAVR EGRWVFIEDL DRAPNEVIST LLPLIETGEL LIPGRGEVIR AARGFKLIAT
     MRSSVNLRGE VTIPGSSMLG GRFWRHIAIQ MPAEQELAEV IAKAYSGLDG HVPSIMAIYS
     RLRALSQRPS FAAESRMGVV RPLTPRDLLK WCSRVSALLS RSSSFTDSHV DDIYLEAVDC
     FAGSLPVGRA REMIVAIVAE ELQIDPQRRD HLLTDRQVKY EPSAKGSGGA FRIGRASLSR
     SRLPASRKTS VKRPFATNGH TVRMLERVAV AVEQREPLLL VGETGTGKTT SIQHLADQLG
     CKLVAFNLSQ QSESGDLLGG FKPVNVRSLI IPMKDDFDDL FASTFQKKEN EKFMQMLGES
     VAKGKWRRVC ILWRKALSMV EDHARKAHRS QTPETEEGEQ PKKKRKVALA KESFPNARWE
     KFAKDFRQLD AQLSARPDAF AFTFVEGNIV KAVRNGDWVL LDEINLASPD TLEALADLLS
     GGPGGSPSIL LTETGDVERV KAHPNFRIFA AMNPATDVGK KDLPAGIRSR FTEIYVESPD
     RDPKSLHSIV ETYIGNATVD SSIAADVTAL YLKIQSFAAQ NMLVDGADQK PHFSLRTLTR
     TLSYAKEIAP QCSLRRALYE GFHMSFLTFL NKTSETLLEP IIKQYLFGKH RNAAAELKKS
     LSRPEDDSRG YVKEGHYWLR QGVFSVEEQP HYIITPFVRR NLDNLIRAAS TRRFPVLIQG
     PTSSGKTSMI EYLAKRSGNK FVRINNHEHT DLQEYLGTYV SGADGKLQFQ EGVLVRALRE
     GHWVVLDELN LAPTDVLEAL NRLLDDNREL LIPETQEVVR PHEDFMLFAT QNPAGLYGGR
     KVLSRAFRNR FLELHFDDIP VEELNEILQK RTQVPPSWSE RIVNVYKELS VMRQENRLFE
     QKSFATLRDL FRWALRKADT VEQLAINGYM LLAERVRKAE ERLAVKAVIE KVLSSKGPRV
     RIDEDSLYDA HKSSDIAQYH SNVPSAGVVW TRAMRRLYVL VAEALRNNEP VLLIGETGCG
     KTTVCQMLAD ASGKDLHIVN AHQNTEAGDL IGAQRPIRNR AAIEASLVDE LRAALGTDAS
     ADTKLGDLLR AYDALGKASL EKQVPPELRR SIAAHRTKAA ALFEWSDGSL VHAMKSGQYF
     LLDEISLADD SVLERLNSVL EPYRSLLLAE KGSDDSFVIG SEGFQFLATM NPGGDYGKKE
     LSPALRNRFT EIWVPAMSDL EDILQIVEAK LNPHAKRFAS ALVSFAQWFN TRYNTSAASS
     ISIRDTLAWV QFINRRSDSD PIFDIVHGAA MVYVDTLGAN PAAILAMSPA SVDEERKQCL
     HHLGKLLGLD AMEIYNTSVD ITASDGWLNI GPFSVPRSPS ATVDARFTSS APTTMSNLVR
     VARALQFTKP VLLEGNPGVG KTTLVTALAK AVGKPLARIN LSEQTDLMDL FGSDVPVEGA
     QAGTFAWRDA PFLRAMKSGE WVLLDEMNLA SQSILEGLNA CLDHRGEVYV TELDQTFTRH
     PDFRVFAAQN PHYQGGGRKG LPASFVNRFT VVYADVFRPE DLLLICKQVF PDYPDDDIQK
     LIRFVAELDA NVVQYRRFGA QGSPWEFNLR DTLRWLQLLT AKDGLLPAGD ARDFLDTVFT
     QRFRNPSDRQ SVASLFSTVF GMTLQQRDYF HNLSSRSLQV GLGCLPREPL LQMSPDSGRC
     FAKPYLAAME SLMICVQQSW PVILVGQSGA GKTSLVKQLA STVGANLVSF SMNADIDAMD
     LVGGYEQVDP SRQVNAFFGK LQTFLQREVV HCVSSESTRL RQASKLLDYF ETSNQTGSLN
     LAEICTALES LGSDSNSVEL QSLVSEAHLL QLRSDTIDRA QFEWVDGLLI QALEQGKWLV
     LDNANLCSSS VLDRLNSLLE PGGYLSINEH TNENGGAKAV KPHPTFRIFM TMDPKYGELS
     RAMRNRAVEI YLLPSTDTQI HEIYPAPITS PLESSIYRFR HIRQSMSSTS ATNGSVIDIS
     LDHLSFEDSP LLSAFREQAV AGLVEFRDAT LQDTFNTKLE GWISAGLLGD WTSMALQWQA
     WLAGFSNSQE DFRQAQTIHP LNNSALVQYN ASNTSQAYSL AALFDVCLDV SKMQQTWNRI
     KRETNEKRVA NMTRLERSFA SAARIPNLAQ ESTAGAAVFL RDAPVDFLGR VRAYWWNFLA
     LVHAPSFDEA VFQVYLTLGQ EALSSFELTM PSSGSLLRAL KRAVASFSAS TKLTTGLSME
     RIWKKFRPQV PPDYGRLQVL LRLEGLADRF DEDMWKFKAS LTELCRIRNA LSDAINLVLT
     EGVDAEGLIN TFDEAINNLS NGTQEDATLT PYFESEFEGI CQYSDISSSD DIQTAQLRPI
     LQLLAGRSTR HTLRRSSPLT RTPAETLKNL SDYLGGDSSD RRAVALNDYL SISLLRRLTG
     VGSVSLAQLD LLDAELKTLG ESVALAAPRF VQDQVSVLDV SLRLLIRELL GAHQHYFEVN
     PGTEAASGFE MTLSSSLPQG HYFRDIFSAF LERPLRYLDT AYAARHEKWA AAGWAWINFA
     LGSMLLYIPD RPFDPALRPA VERQWFANYK SDVEGKLIAL QQFELLFTGQ LENLRTRLLE
     RELVELGAEP VVPAIARPPM SELNQLQGEF TNLLGLLKTV VSATREKGSE PIQDSTLQQN
     LLRINERFST GYRAYDDITA PVVGFLHCLN VGIGLVSAGE RRTRPTPDHF YLESVLHRAN
     AFLGRAKDYW LDGYLAQPIH LTMVEPAIRL HRLASLSLGV SIQPERSGPA RVRTVIHDCF
     ESFYRTWKEQ LSSDQQKAAM KSSLFRYRDG QEVEDDAAED EFQDLFPSYE QEKALNLTSE
     DVSFQDLAPE LSDLHAAIFV NRQEPVAKMR ALLERSAKIL ATYSNDAESI IPTKATLPSV
     FLMIQEKLGS LQNIDGPRRT YNIYTDPNII EARKLVALVQ RLQRRFRQLR EVWPEHATLS
     EVLNICTELL AFRHMEPVAK LLTKGEQLHA TVYEWQRVAS KEYSAASLYD ELTNLLISWR
     QLELTTWARL FDIEAEKCVE DAKRWWFVAY ENIVAVPEAL LSSEQDMKTH ARELVKTLES
     FIHSTSAGQY QQRLRLLEQF QEHLAMRIQD EPALQPVHAA LAHFIKFFAR FEQPVNATLA
     KGRQTLEKDM RNVIQLAGWR DRTIDALRQS AKTSHRKLFK LVRKFRALLG QPVDAILKQG
     LPDLIFPDLT ERHMPIRSDA DSKALEECES GISEWVSRPT RFINLTATTS LMRKMARANE
     LAVDGPAYIE SFLSNLESEM VKLRKATPSI LTEENKDTVQ QLKSRKRRLF ADTLKELRQM
     GFKSNLGGDV LEMQESLSTV LASLPVLPKA CGDELQAAAE HHLYKALDLM ASVRDVKREH
     SGDLTANEVA RSVGFLESLL HTSITQRTFL SQSITHSSTL GAVVKQAEAL WAPDKYELYP
     ASLHDTLAAN TSERIVAWLL PIATLGADVV AAQATLGKFD VSALVNDLRS YAAAFQALNE
     ETRSLPPAPE GLQTSSHMEL DDRRQVAMKE FNHILHGWKE TYPVLAPVLD HMIPWADYED
     STTPNGHIIN GTRNLEADTV RDQMFKTLDD ILGSIQDLEK AQTSLPTSVE DATWFMTEEQ
     TITRSLAALQ GPRIAASLSA LLGGLRHVNV LRSATALFAA VLSILQQYVQ IYQEALARFA
     SHHQATTKMT CRLAKAFIQI GTQGFCMPSE KSDEKGDSGD KLEEGTGLGE GEGAEDISKD
     IQDDEDLTEL AQEPNQKTDR EEIEDEKDAV DMADQEMEGD MGDAPEKDED DEAQSGDEGD
     NESIDEEAGD VDDLGPSTLD EKMWDDGGEE ADKDKEGDQN KGMSKKDEQV AGQDKEGKPE
     EQQGEEMEEE IEAGAEESEM VGREEMEKTD PHLQEGETLD LPDELDMDNK SEGSQHDSDF
     EGMEDIQDGR EEDAEEPDGP GDTATPPDER DATPTEDAEV MQEETGDEQE AEKATEPENT
     DEAEQGAEDE GQLQLADERA GAEDVAESEV RGAGTNAQEQ AMEDQQATAS ASKQEEGSKG
     EASEQEEVQA SAEDGQRGQA STRDAVGKSD DDLQDSADSQ PFKKLGDALE QWYNQRRQIR
     DAIKDQEPLN QQLNQDVDMA DAEFEHLHDD QTQADTQALG AAQEEQVRAL DENKALASND
     QEQATEAVPD YVDVDGDEVE DAPMQDHEPS ATTQPRGGEE GRPNAFQGDH KDMPIDQLDD
     HMDGIDDERE DDVEEVDTAL STIHLDQSTP TPRSADEARR LWTHHESSTR TLSQSLTEHL
     RLILAPTLAT KLRGDFRTGK RLNMKRIIPY IASSYKRDKI WLRRSQPSKR SYQIMLALDD
     SKSMAEGGSA DLAFETLALV SRSLSMLEAG ELCVVRFGEN VEVAHPFETP FSSEAGVEVF
     RRFGFQQQKT DVRKLVTDGI ELFREARMRA TSSGAELWQL LIIISDGICE DHATIQRLIR
     QAMEEKIMVV FVIVDAANQA PPQGKAEGSK GGQSILDLQT ADFVQVGQDF KVVTKKYLDT
     FPFRYYLVVR DVKELPGVLA TALRQWFAEV VDTAG
//