ID   R7YW82_CONA1            Unreviewed;       661 AA.
AC   R7YW82;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Methylenetetrahydrofolate reductase (NADPH) {ECO:0000313|EMBL:EON66064.1};
GN   ORFNames=W97_05307 {ECO:0000313|EMBL:EON66064.1};
OS   Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetes incertae sedis; Coniosporium.
OX   NCBI_TaxID=1168221 {ECO:0000313|EMBL:EON66064.1, ECO:0000313|Proteomes:UP000016924};
RN   [1] {ECO:0000313|Proteomes:UP000016924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 100218 {ECO:0000313|Proteomes:UP000016924};
RG   The Broad Institute Genome Sequencing Platform;
RA   Cuomo C., Gorbushina A., Noack S., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The genome sequence of Coniosporium apollinis CBS 100218.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
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DR   EMBL; JH767578; EON66064.1; -; Genomic_DNA.
DR   RefSeq; XP_007781381.1; XM_007783191.1.
DR   AlphaFoldDB; R7YW82; -.
DR   STRING; 1168221.R7YW82; -.
DR   GeneID; 19902618; -.
DR   eggNOG; KOG0564; Eukaryota.
DR   HOGENOM; CLU_025841_2_2_1; -.
DR   OMA; VARTSQW; -.
DR   OrthoDB; 1381745at2759; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000016924; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016924}.
FT   REGION          597..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        622..643
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  74466 MW;  11F59738A1AABFB7 CRC64;
     MHISEKLAEA QKAGKPSYSF EFFPPKTAQG VQNLYDRMDR MHGFGPSFID VTWGAGGRHS
     QLTCEMVKTA QSAYGLETCM HLTCTDMDKS KIDDALREAY NAGCTNILAL RGDPPREREK
     WEAKAGGFRY AKDLVKYIKE KYGNHFDIGV AGYSEGCEDQ EDADLLIDHL KEKVDAGGTF
     VITQMFYDVD IFLDWVKKCR AKGITVPIIP GIMPIHTYAA FLRRAHWTKC HVPEEWTKAL
     EPVKNDDAEV REVGKDLVAK MCRRLLDAGI IHLHFYTMNL AQATRMVLEE LGITPDLESP
     LDKPLPWRQS LGLNRRDENV RPIFWRNRNR SYVARTQDWD EFPNGRWGDS RSPAFGELDA
     YGIGLKGTNE QNVKLWGQPR SVKDIANLFV RYMQGKLESL PWSEAPISSE ADVIKDNLID
     LNQRGLLTIN SQPAVDGAKS SDPVYGWGPR NGYVYQKAYL EVLVSPEVIA ELITRIERNP
     DLTYYAVNKQ GDLKTNAPGD GPNAVTWGVF PGKEIVQPTI VETISFLAWK DEFFRLGHDW
     ASCYSAANPS RYVIRDLMDN WYLVNIVHND FHERHGIFPL FEGLEIKDME KPLHVNGEVA
     TNGDAPESKP ATNGDRTAEP KPSTNGTKEE EKPAVDDGTE GWAKPAKKSN APLPQTFPVP
     P
//