ID R7YYJ4_CONA1 Unreviewed; 396 AA.
AC R7YYJ4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming) {ECO:0000256|ARBA:ARBA00038984};
DE EC=1.1.1.179 {ECO:0000256|ARBA:ARBA00038984};
DE AltName: Full=D-xylose-NADP dehydrogenase {ECO:0000256|ARBA:ARBA00042988};
GN ORFNames=W97_06093 {ECO:0000313|EMBL:EON66977.1};
OS Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Coniosporium.
OX NCBI_TaxID=1168221 {ECO:0000313|EMBL:EON66977.1, ECO:0000313|Proteomes:UP000016924};
RN [1] {ECO:0000313|Proteomes:UP000016924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 100218 {ECO:0000313|Proteomes:UP000016924};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Gorbushina A., Noack S., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Coniosporium apollinis CBS 100218.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH;
CC Xref=Rhea:RHEA:22000, ChEBI:CHEBI:15378, ChEBI:CHEBI:15867,
CC ChEBI:CHEBI:53455, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.179; Evidence={ECO:0000256|ARBA:ARBA00036678};
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family.
CC {ECO:0000256|ARBA:ARBA00010928}.
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DR EMBL; JH767584; EON66977.1; -; Genomic_DNA.
DR RefSeq; XP_007782294.1; XM_007784104.1.
DR AlphaFoldDB; R7YYJ4; -.
DR STRING; 1168221.R7YYJ4; -.
DR GeneID; 19903404; -.
DR eggNOG; KOG2741; Eukaryota.
DR HOGENOM; CLU_023194_5_2_1; -.
DR OMA; EEAFHWQ; -.
DR OrthoDB; 5486222at2759; -.
DR Proteomes; UP000016924; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR22604; OXIDOREDUCTASES; 1.
DR PANTHER; PTHR22604:SF105; TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016924}.
FT DOMAIN 50..147
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
SQ SEQUENCE 396 AA; 44344 MW; A7D4496E2D02D4C9 CRC64;
MALIVQAYTF LQQYAVSWME AVPKKNSGAI RLGVLSTAQI NPAAAFHPAE THPDVILYAI
ASRDAASAQK TAKQYKFQKS YGSYQALLDD PEVDAVYVST PNGMHYEWAH KALKAGKHVL
LEKPFTSNGE EARKLVETAQ QTGKVLEEAF HWQFHPAAHA WREIIDSGKY GPIIATDSRM
TASPGVPHGD IRWQYDLAGG SFMDCTYALS FTRYALHAET PVKVLSAVAR PYEKDERVDA
GMHTTLLFKD KRGDIVQSRV YTDLARSWVS GFIPRAWEFP AIEVETDKAV IYFYNAMMPH
LYHYISVTEK ATGKTTVKKQ YKGGPKWGDV ETSGGKGGRP SWSTYRYQME AFVDRIKGKE
PACWVPNEDS IAQMESIDAV YEHSGLGKRP SRSLEE
//
