ID R7Z4Z3_CONA1 Unreviewed; 868 AA.
AC R7Z4Z3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 13-SEP-2023, entry version 43.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN ORFNames=W97_08516 {ECO:0000313|EMBL:EON69158.1};
OS Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Coniosporium.
OX NCBI_TaxID=1168221 {ECO:0000313|EMBL:EON69158.1, ECO:0000313|Proteomes:UP000016924};
RN [1] {ECO:0000313|Proteomes:UP000016924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 100218 {ECO:0000313|Proteomes:UP000016924};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Gorbushina A., Noack S., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The genome sequence of Coniosporium apollinis CBS 100218.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR EMBL; JH767608; EON69158.1; -; Genomic_DNA.
DR RefSeq; XP_007784475.1; XM_007786285.1.
DR AlphaFoldDB; R7Z4Z3; -.
DR STRING; 1168221.R7Z4Z3; -.
DR GeneID; 19905827; -.
DR eggNOG; KOG0436; Eukaryota.
DR HOGENOM; CLU_330373_0_0_1; -.
DR OMA; TFIVCEP; -.
DR OrthoDB; 166496at2759; -.
DR Proteomes; UP000016924; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000016924};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..868
FT /note="methionine--tRNA ligase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004451129"
FT DOMAIN 332..699
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT REGION 176..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 95577 MW; 4038852BA38AEC59 CRC64;
MRIATIALAI TLGLAVQVAA DPKRKWGSRF CHKTGQGCPR LKRAAEPLPL PDTETLKRAE
AEAVKSYIAK RDLKTDAKDS GICWQPNQAC DKLKRAVEEA TDELLSVPGY ELDESDAASQ
DICGAPNKPC HKAKRSAEAL AAAIAEAAPF AFPEADPKRK WGSRFCHKTG QGCPRVKRDG
TLEAPSPPAD TPADPATDVE ENLEVDPEAE ADAVRFCHLP AQECDKIHRA AQVIENSLDG
AEPSVDGSAL CSLPGHDCHK AKTAAKALAQ AALDAVSNIP VPEADAAGPH GPSGPFASFN
AAARKLSRPY RAMRSRIFRA ATSAKSEQEK PYYLTTPIFY VNAAPHVGHL YTMVLTDILK
RWQLLRGRTA ILCTGTDEHG MKIQQASSQA GSEPKPFCDK GAEVFKRLAA RAGVLNDHFV
RTTDPEHKEA VQYAWFLLRE RGYIYTSKHE GWYSVSDETF YPQSQVHLIL DPATGPSLKT
SMETGKEVEW TSEINYHFRL SAFRDRLLSF YAENPEWIKP ASRMADVVQA VSSGLEDLSI
SRPVERLSWG IRVPDDESQT IYVWLDALVN YITKAGYPWQ PGKEHVQGWP ADVQVIGKDI
VRFHCIYWPA FLFALDIPPP RNILTHAHWT LGKQKMAKST GNVVNPFFAL DRFGVDTMRY
YLAHDGGIAQ DADYSNYYII ERYKKGLQGG LGNLASRVMR AKGWSVRRAV LDMCHEIADA
SPSDASAAAQ RAMLLELPEA VAKEFGDLNV GSALKVIMDA VYETNKYLHA ASPWKQVPEF
EKGSSPPRVP EIDRTIFLCA EALRVVGILL QPYVPNKAAQ LLDMLGVQTD RRSLEYARLG
SDDSYGESSV ELGRGPQGTL FPPLASDL
//