ID R7ZC04_LYSSH Unreviewed; 566 AA.
AC R7ZC04;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN ORFNames=H131_16368 {ECO:0000313|EMBL:EON71559.1};
OS Lysinibacillus sphaericus OT4b.31.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1285586 {ECO:0000313|EMBL:EON71559.1, ECO:0000313|Proteomes:UP000013911};
RN [1] {ECO:0000313|EMBL:EON71559.1, ECO:0000313|Proteomes:UP000013911}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OT4b.31 {ECO:0000313|EMBL:EON71559.1,
RC ECO:0000313|Proteomes:UP000013911};
RA Pena-Montenegro T.D., Dussan J.;
RT "Draft genome of the heavy metal tolerant bacterium Lysinibacillus
RT sphaericus strain OT4b.31.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON71559.1}.
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DR EMBL; AQPX01000022; EON71559.1; -; Genomic_DNA.
DR RefSeq; WP_010860206.1; NZ_KB933398.1.
DR AlphaFoldDB; R7ZC04; -.
DR PATRIC; fig|1285586.5.peg.3410; -.
DR eggNOG; COG4477; Bacteria.
DR HOGENOM; CLU_034079_1_0_9; -.
DR OrthoDB; 1654473at2; -.
DR Proteomes; UP000013911; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..2
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 22..566
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 101..143
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 249..276
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 369..424
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 566 AA; 65879 MW; 69C6D64DE89E941E CRC64;
MEYIIIPIIL LLILAIVGFM MRRKHTAIIE QLENEKLQIQ NNPINEEISK VKSLNMNGET
EEMFERWRNS WDEVIDVHMT KIDSLLFDAE DQVNHLRFKK ATLIEREIED YVRKCEQSKD
KILEELNELI GSEEKNRIEI EQLKEYYRSA RKTLLAHQHS FGIALPALEQ KLEVFVQKFE
EFDELTRDGN YLQAREIVIG LNHESQETFE YINDVPTILT ELQVKLPGAV QELRNGQREM
EEKSYYLHHL ELAEALDNLE TEFANLKDEL AQLNLSSVKP RVVEINEEID HFYDLLEKEV
IAKNYVDQNC ERLLGSITNV ISSTRLVNDE ATFVQQSYHL NEKDAEIPKA ALKQLEALQR
RYDLLAMRVT EEKSAYSSLQ EELIEISEEL ERIHEEQDHL SNTMKKLRID ENKACAQVEN
LKKTLQDTDR LLNKANIPGI PEEMDARLDE AAEHIYVVMQ SLQEVPLNMG TVHNNLNAAT
LCVEDVHSKA HELIENVMLI ERIIQYGNRH RATNPKLNTR LKEAEEAFHQ FRYTKALEEA
GTAVEEMEPG ALKRIQEIVA EDLVAR
//
