ID R7ZRX7_9BACT Unreviewed; 527 AA.
AC R7ZRX7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ADIS_2708 {ECO:0000313|EMBL:EON76837.1};
OS Lunatimonas lonarensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae.
OX NCBI_TaxID=1232681 {ECO:0000313|EMBL:EON76837.1, ECO:0000313|Proteomes:UP000013909};
RN [1] {ECO:0000313|EMBL:EON76837.1, ECO:0000313|Proteomes:UP000013909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK24 {ECO:0000313|EMBL:EON76837.1,
RC ECO:0000313|Proteomes:UP000013909};
RA Singh A.;
RT "A novel strain isolated from Lonar lake, Maharashtra, India.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON76837.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQHR01000073; EON76837.1; -; Genomic_DNA.
DR RefSeq; WP_010854843.1; NZ_AQHR01000073.1.
DR AlphaFoldDB; R7ZRX7; -.
DR STRING; 1232681.ADIS_2708; -.
DR PATRIC; fig|1288963.3.peg.2698; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000013909; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EON76837.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000013909};
KW Transferase {ECO:0000313|EMBL:EON76837.1}.
FT DOMAIN 9..143
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 153..488
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 527 AA; 59302 MW; FB46B515560DB3E0 CRC64;
MTQSDIKNLE KELWDAADEL RGNSKLTAAE YKDPLLGLVL LRFAQNRYED AKVQVEKNLA
INPRTGEKRQ ATKDDFAAAG AIMLPEQAKY DYLVDLPESV DIAEAINNAM KLIEAEYPDL
AGILPKSYQE FDAKLLRDLI RVFNSDAVKN AKGDVFGRIY EFFLMKFSMQ GAGAQEGGEF
FTPPSLVNLI INFIQPNHGI IHDPACGSGG MFVQTAHFIK DHDPNRSVNE AITVYGTELK
SNNAKLAKMN LAIHGIEGKI MESNSFYTNP FNLTGKCDFV MANPPFNVDR VDAKNKFLTE
DDRLPFGAPL TGKGTIGNGN YLWAQYFYSY LNETGRAGFV MASSATDAGN AEKLIRQKLI
ETGHVECIVS VGNNFFYTRS LPCHLWFYNK GKKPENKNKI LMIDARNVYR KVTTTINDFS
EEQLEGLTAL INAFRGDELG VSRDNEWFNE HFPDGQYRDV EGLCKVVDLE EIIEQDYSLT
PGRYVGVSIE LDMDFDYQGR IKEIHSELAD LNQEANRLMS QIQSLEL
//
