ID R7ZSH8_9BACT Unreviewed; 692 AA.
AC R7ZSH8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=ADIS_2491 {ECO:0000313|EMBL:EON77042.1};
OS Lunatimonas lonarensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae.
OX NCBI_TaxID=1232681 {ECO:0000313|EMBL:EON77042.1, ECO:0000313|Proteomes:UP000013909};
RN [1] {ECO:0000313|EMBL:EON77042.1, ECO:0000313|Proteomes:UP000013909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK24 {ECO:0000313|EMBL:EON77042.1,
RC ECO:0000313|Proteomes:UP000013909};
RA Singh A.;
RT "A novel strain isolated from Lonar lake, Maharashtra, India.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON77042.1}.
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DR EMBL; AQHR01000068; EON77042.1; -; Genomic_DNA.
DR AlphaFoldDB; R7ZSH8; -.
DR STRING; 1232681.ADIS_2491; -.
DR PATRIC; fig|1288963.3.peg.2483; -.
DR Proteomes; UP000013909; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 2.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 4.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000013909};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 611..692
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 692 AA; 79693 MW; 9F490FBD03BCD150 CRC64;
MNFLENHFGE EFSERQLSKQ LKLRVAKEKQ DLSDVLLELL SAGKVSKNAR NAFSTTADPE
FVEGEVDYVN ARFAFVIPKS MTKAEDDILV REKDLKNALD GDTVRVMVFP GRAHNGRREG
KVLEILSRCR DEFVGRVEIS PRYAFVVPDF KKMHRDIFVK KSDLLGAQHN QKVVVKLTEW
NEQDKNPTGA IVRILGTAGE HEVEIHSIMA EFGLPFDYPE EAEAEADQIA EAIGADEIKG
RRDFRGVPTF TIDPADAKDF DDAISYRKLD NGNYEVGVHI ADVTHYVRPN TLLEREAYHR
ATSVYLVDRT IPMLPERLSN GLCSLRPNED KLTFSCVFEI TEDAAVLDFW IGRTVIHSDR
RFAYEEAQEN IDQQSGDFYG ELTLLNGLAK KLRAERFKKG AINFETVEVK FKLDDKGKPL
GLIIKERKDI HKMIEEFMLL ANRTVAEFIF NRNKGKDTFV YRIHDYPDLE KLTTFAGFAR
KFGHELSITD ERTVSKTLNK LMDDIVGKPE QNVLEQLAIR SMAKAKYTTE PKLHFGLAFK
HYTHFTSPIR RYPDMMVHRL LQHYLDGGKN MENQSWEEKC THSSEREKRA SDAERASIKY
KQVEFMQLAE VKDYDGIVTG VTEWGVYVEI TETKCEGMVR LQDIKDDYYD FDERNMRLVG
SKNKRIITLG DKVSVRVLKT DIDRRTIDLE FV
//
