ID R7ZU77_9BACT Unreviewed; 592 AA.
AC R7ZU77;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ADIS_1914 {ECO:0000313|EMBL:EON77695.1};
OS Lunatimonas lonarensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae.
OX NCBI_TaxID=1232681 {ECO:0000313|EMBL:EON77695.1, ECO:0000313|Proteomes:UP000013909};
RN [1] {ECO:0000313|EMBL:EON77695.1, ECO:0000313|Proteomes:UP000013909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK24 {ECO:0000313|EMBL:EON77695.1,
RC ECO:0000313|Proteomes:UP000013909};
RA Singh A.;
RT "A novel strain isolated from Lonar lake, Maharashtra, India.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON77695.1}.
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DR EMBL; AQHR01000050; EON77695.1; -; Genomic_DNA.
DR RefSeq; WP_010854052.1; NZ_AQHR01000050.1.
DR AlphaFoldDB; R7ZU77; -.
DR STRING; 1232681.ADIS_1914; -.
DR PATRIC; fig|1288963.3.peg.1905; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000013909; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EON77695.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000013909};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EON77695.1}.
FT DOMAIN 10..143
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 155..465
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 487..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 68467 MW; C04131E0323E93FB CRC64;
MSNRKVDVGF IFQITDKVLW NVFKKNEIGD VLLPFVVLRR LDCILDPVNQ KVRDAYNNFK
DKVTEDKLDP ILRKAAGGLQ FYNISRHTLE SLRENPKTIE IDFNNYLYGF NKEVREIIEC
FQFDKVLGRL LKNRILYQMI DAICKVDLHT DKVDNHDMGY VFEELIRISN EQSNETAGEH
FTPRDVIQLM IEVMFSTEKE VFSQPGIIRT IYDPAMGTGG MINIAKNYVV DVLSANQTNK
PTIRTYGQEI NEQSYAIAKS EALITGENID NIRHGNTFTK DRFTDKKFHY MLANPPYGVT
WSKDADYIIN ESANPAGRFY AGLPAKSDGQ LLFLQHMISK MEYEGSKIAV VTNGSPLFSG
GAGSGESDIR KWIISSDWLE CIVALPKDLF YNTGINTFIW FLTNNKPSHR RGKVQLINAV
EAEDKINEKT GFCRPEKRSL GNKRNKIEDY HIQRIVDLYT RFEEGRYSKI FDNEYFGYYQ
VTIEQPELDE NGKPKEGRNG EWKADSKKRD KENIPLSEDI EIYFEKEVLP HIGKGWIDYD
KTRIGYEINF SKYFAEFKPL RPTQEIKAEI QELEFGNKND KGIMELLKEL LG
//
