ID R8ALN7_PLESH Unreviewed; 422 AA.
AC R8ALN7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=DNA polymerase I {ECO:0000313|EMBL:EON87251.1};
GN ORFNames=PLESHI_16867 {ECO:0000313|EMBL:EON87251.1};
OS Plesiomonas shigelloides 302-73.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Plesiomonas.
OX NCBI_TaxID=1315976 {ECO:0000313|EMBL:EON87251.1, ECO:0000313|Proteomes:UP000014012};
RN [1] {ECO:0000313|EMBL:EON87251.1, ECO:0000313|Proteomes:UP000014012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=302-73 {ECO:0000313|EMBL:EON87251.1,
RC ECO:0000313|Proteomes:UP000014012};
RX PubMed=23814109;
RA Pique N., Aquilini E., Alioto T., Minana-Galbis D., Tomas J.M.;
RT "Genome Sequence of Plesiomonas shigelloides Strain 302-73 (Serotype O1).";
RL Genome Announc. 1:e00404-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: Single-chain monomer with multiple functions.
CC {ECO:0000256|ARBA:ARBA00011541}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON87251.1}.
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DR EMBL; AQQO01000371; EON87251.1; -; Genomic_DNA.
DR AlphaFoldDB; R8ALN7; -.
DR PATRIC; fig|1315976.3.peg.3229; -.
DR HOGENOM; CLU_004675_2_1_6; -.
DR Proteomes; UP000014012; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000014012}.
FT DOMAIN 179..386
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 422 AA; 46589 MW; 2CBA53B1FEC0D721 CRC64;
MHEVLWPQLE QEAGLASVLQ EMEVPLLSVL SRMERNGVLI DPALLGRHSM ELTARLAELE
SKAHELAGEP FNLASTKQLQ GILFEKLGLP VLKKTPGGAP STNEEVLAEL ALDYPLPAVL
LEYRGLAKLK STYTDKLPQM INPATGRVHT SYHQAVTATG RLSSTDPNLQ NIPVRNEEGR
RIRQAFIAGA GNQIIAADYS QIELRIMAHL SGDAGLLRAF SEGKDIHRAT AAEVFGLPLE
QVSAEQRRSA KAINFGLIYG MSAFGLARQL GIGRNDAQRY MDLYFERYPG VLTYMERTRE
QAHAQGYVET LFGRRLQLPD IRSRNAMRRK GAERAAINAP MQGTAADIIK RAMLAVDAWL
ATPEADGIRM IMQVHDELVF EVPQEKVALC SAKVRELMQQ SAALDVPLLV EVGVGDNWDQ
AH
//
