ID R8AP25_PLESH Unreviewed; 393 AA.
AC R8AP25;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 08-NOV-2023, entry version 38.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EON88081.1};
GN ORFNames=PLESHI_12330 {ECO:0000313|EMBL:EON88081.1};
OS Plesiomonas shigelloides 302-73.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Plesiomonas.
OX NCBI_TaxID=1315976 {ECO:0000313|EMBL:EON88081.1, ECO:0000313|Proteomes:UP000014012};
RN [1] {ECO:0000313|EMBL:EON88081.1, ECO:0000313|Proteomes:UP000014012}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=302-73 {ECO:0000313|EMBL:EON88081.1,
RC ECO:0000313|Proteomes:UP000014012};
RX PubMed=23814109;
RA Pique N., Aquilini E., Alioto T., Minana-Galbis D., Tomas J.M.;
RT "Genome Sequence of Plesiomonas shigelloides Strain 302-73 (Serotype O1).";
RL Genome Announc. 1:e00404-13(2013).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON88081.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQQO01000355; EON88081.1; -; Genomic_DNA.
DR RefSeq; WP_010864072.1; NZ_KB944511.1.
DR AlphaFoldDB; R8AP25; -.
DR STRING; 703.SAMEA2665130_02024; -.
DR PATRIC; fig|1315976.3.peg.2329; -.
DR HOGENOM; CLU_031026_0_1_6; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000014012; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF144; ACYL-COA THIOLASE-RELATED; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000014012};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EON88081.1}.
FT DOMAIN 5..261
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 270..390
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 378
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 393 AA; 40172 MW; 024DC21616F68383 CRC64;
MSKEIVVLSA VRTPMGGFQG SLSGFTAPQL GAEVVKAAIE RAGIQPAQVD EVLLGCVLPA
GLGQAPARQA ALVAGVPDSV PCTTVNKVCG SGMKTLMQGA AALKLGEADV VVAGGMESMS
QAPYLMPAAR TGLRMGHGAV KDHMFTDGLE DSYSGKLMGV LAQQMADKRG VTREAMDNFA
INSLAKANAA IAQGAFEAEI VPVTVVTRSG NTQVCIDEQP GNAKPEKIPG LRPAFAKDGT
ITAANSSSIS DGAAALVLST ADYAAQNGCK PLARIVSYAS HAQAPEEFTV APVGAIRKAI
DLAGWTPDDI DLFEVNEAFA MVTLLAIEDV GLDSNKVNVH GGACALGHPL GASGARVVVS
LIHALRRYGK KRGLAALCIG GGEGVAMTVE LID
//
